Toxicological Impact of Air Pollution Particulate Matter (PM_2.5) Collected under Urban, Industrial or Rural Influence: Occurrence of Oxidative Stress and Inflammatory Reaction in BEAS-2B Human Bronchial Epithelial Cells (Corrected Version)

Abstract:

Exposure to air pollution Particulate Matter (PM) is one of the risk factors involved in the high incidence of respiratory and cardio-vascular diseases. In this work, to integrate inter-seasonal and inter-site variations, fine particle (PM_2.5) samples have been collected in spring-summer 2008) and autumn 2008-winter 2009, in Dunkerque (France) under urban or industrial influence, and in Rubrouck (France), under rural influence. Attention was paid to characterize their physico-chemical characteristics, and to determine their ability to induce oxidative stress and inflammatory response in a human bronchial epithelial cell model (BEAS-2B cell line). Physico-chemical characterization of the six PM samples showed their heterogeneities and complexities depending upon their respective natural and/or anthropogenic emission sources. Lung cytotoxicity of these air pollution PM_2.5 samples, as shown in BEAS-2B cells, might rely on the induction of oxidative stress conditions and particularly on the excessive inflammatory response.

• Periodical: Advanced Materials Research (Volume 324)
• Pages: 489-492
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.324.489
• Online since: August 2011
• Authors: Mona Dergham, Sylvain Billet, Anthony Verdin, Dominique Courcot, Fabrice Cazier, Pirouz Shirali, Guillaume Garçon
• Keywords: Air Pollution Particulate Matter (PM_2.5), BEAS-2B Cells, Cytotoxicity, Industrial Influence, Inflammatory Response, Oxidative Stress, Physico-Chemical Characterization, Rural Influence, Urban Influence

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