Toxicological Impact of Air Pollution Particulate Matter (PM2.5) Collected under Urban, Industrial or Rural Influence: Occurrence of Oxidative Stress and Inflammatory Reaction in BEAS-2B Human Bronchial Epithelial Cells (Corrected Version)

Abstract:

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Exposure to air pollution Particulate Matter (PM) is one of the risk factors involved in the high incidence of respiratory and cardio-vascular diseases. In this work, to integrate inter-seasonal and inter-site variations, fine particle (PM2.5) samples have been collected in spring-summer 2008) and autumn 2008-winter 2009, in Dunkerque (France) under urban or industrial influence, and in Rubrouck (France), under rural influence. Attention was paid to characterize their physico-chemical characteristics, and to determine their ability to induce oxidative stress and inflammatory response in a human bronchial epithelial cell model (BEAS-2B cell line). Physico-chemical characterization of the six PM samples showed their heterogeneities and complexities depending upon their respective natural and/or anthropogenic emission sources. Lung cytotoxicity of these air pollution PM2.5 samples, as shown in BEAS-2B cells, might rely on the induction of oxidative stress conditions and particularly on the excessive inflammatory response.

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Periodical:

Edited by:

Maher Soueidan, Mohamad Roumié and Pierre Masri

Pages:

489-492

DOI:

10.4028/www.scientific.net/AMR.324.489

Citation:

M. Dergham et al., "Toxicological Impact of Air Pollution Particulate Matter (PM2.5) Collected under Urban, Industrial or Rural Influence: Occurrence of Oxidative Stress and Inflammatory Reaction in BEAS-2B Human Bronchial Epithelial Cells (Corrected Version)", Advanced Materials Research, Vol. 324, pp. 489-492, 2011

Online since:

August 2011

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$35.00

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