Although manufactured nanomaterials have a great many of fantastic functions，the adverse impacts about them have been observed. As a kind of nanomaterial, biomedical films obtained from electrospinning are valued greatly, and the sizes of the diameters in electrospun films plays a fundamental role in enhancing the safety of films. When the diameter of fibers increased to hundreds of nanometers, it will become difficult for fibers to diffuse and infiltrate into human’s body, and then the security of the biomedical films is enhanced greatly. In our work, high viscosity polymer and high viscosity solution are electrospun to increase the diameter of fibers. Besides, melt-eletrospinning is introduced as an alternative candidate for improving the security of biomedical films, especially no poisonous solvent exists.