Protective Effects of Hyperoside from Hawthorn against Endothelia Cell Apoptosis Induced by H2O2

Abstract:

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Hyperoside is a flavonol glycoside extraction from Hawthorn (Crataegus), and it has been reported that hyperoside process anti-inflammatory and anti-oxidative effect in vivo. In this paper, we studied the effects of hyperoside on apoptosis, necrosis, intracellular ROS level, mitochondrial transmembrane potential, and expression of Bax and Bcl-2 of endothelial cells subjected to H2O2,. The results showed that hyperoside treatment (50 μmol/L and 200 μmol/L ) significantly reduced apoptosis and necrosis, intracellular ROS and the expression of Bax in endothelial cell subjected to H2O2, and increased mitochondrial transmembrane potential and Bcl-2 expression. In conclusion, the present study indicates that hyperoside is in favor of endothelial cell protection.

Info:

Periodical:

Advanced Materials Research (Volumes 343-344)

Edited by:

David Wang

Pages:

1007-1014

DOI:

10.4028/www.scientific.net/AMR.343-344.1007

Citation:

Y. K. Ge and X. X. Zheng, "Protective Effects of Hyperoside from Hawthorn against Endothelia Cell Apoptosis Induced by H2O2", Advanced Materials Research, Vols. 343-344, pp. 1007-1014, 2012

Online since:

September 2011

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Price:

$35.00

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