Protective Effects of Hyperoside from Hawthorn against Endothelia Cell Apoptosis Induced by H₂O₂

Abstract:

Hyperoside is a flavonol glycoside extraction from Hawthorn (Crataegus), and it has been reported that hyperoside process anti-inflammatory and anti-oxidative effect in vivo. In this paper, we studied the effects of hyperoside on apoptosis, necrosis, intracellular ROS level, mitochondrial transmembrane potential, and expression of Bax and Bcl-2 of endothelial cells subjected to H₂O₂,. The results showed that hyperoside treatment (50 μmol/L and 200 μmol/L ) significantly reduced apoptosis and necrosis, intracellular ROS and the expression of Bax in endothelial cell subjected to H₂O₂, and increased mitochondrial transmembrane potential and Bcl-2 expression. In conclusion, the present study indicates that hyperoside is in favor of endothelial cell protection.

• Periodical: Advanced Materials Research (Volumes 343-344)
• Pages: 1007-1014
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.343-344.1007
• Online since: September 2011
• Authors: Ya Kun Ge, Xiao Xiang Zheng
• Keywords: Apoptosis, Endothelial Cell, Hyperoside, ROS

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