Protective Effects of Hyperoside from Hawthorn against Endothelia Cell Apoptosis Induced by H2O2
Hyperoside is a flavonol glycoside extraction from Hawthorn (Crataegus), and it has been reported that hyperoside process anti-inflammatory and anti-oxidative effect in vivo. In this paper, we studied the effects of hyperoside on apoptosis, necrosis, intracellular ROS level, mitochondrial transmembrane potential, and expression of Bax and Bcl-2 of endothelial cells subjected to H2O2,. The results showed that hyperoside treatment (50 μmol/L and 200 μmol/L ) significantly reduced apoptosis and necrosis, intracellular ROS and the expression of Bax in endothelial cell subjected to H2O2, and increased mitochondrial transmembrane potential and Bcl-2 expression. In conclusion, the present study indicates that hyperoside is in favor of endothelial cell protection.
Y. K. Ge and X. X. Zheng, "Protective Effects of Hyperoside from Hawthorn against Endothelia Cell Apoptosis Induced by H2O2", Advanced Materials Research, Vols. 343-344, pp. 1007-1014, 2012