Proteomics Study on Cross-Linking Reaction of Formaldehyde and HSA

Abstract:

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Possible clinical diagnosis biomarkers of diabetes were proposed using proteomics and bioinformatics methods through the preliminary study on the formaldehyde-human serum albumin crosslinkage. Using LC/MS techniques, the experiment on in vivo cross-linking reaction of formaldehyde with pure protein or plasma protein revealed that the cross-linking reaction of human serum albumin and forrmaldehyde would occur and the concentrations of some normal peptides would change. A group of significant peptides of human serum albumin were selected. As the results of in vivo cross-linking reaction, Non-enzymatic glycosylation modification of HSA were observed in diabetic. The same change of the concentrations of some peptides happened. The above-mentioned results were demonstrated with the hematoplasmas of normal people and diabetics.

Info:

Periodical:

Advanced Materials Research (Volumes 343-344)

Edited by:

David Wang

Pages:

1035-1041

DOI:

10.4028/www.scientific.net/AMR.343-344.1035

Citation:

B. Li et al., "Proteomics Study on Cross-Linking Reaction of Formaldehyde and HSA", Advanced Materials Research, Vols. 343-344, pp. 1035-1041, 2012

Online since:

September 2011

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Price:

$35.00

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