Crystal Structure Analysis and Antinociceptive Property of Lappaconitine Hydrochloride

Wen Xiu Sun; Tun Galag Dong; Chun Ming Ding

doi:10.4028/www.scientific.net/AMR.343-344.1049

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 343-344Crystal Structure Analysis and Antinociceptive...

Crystal Structure Analysis and Antinociceptive Property of Lappaconitine Hydrochloride

Abstract:

An alkaloid compound, lappaconitine Hydrochloride, was synthesized with lappaconitine which was isolated from the root of Aconitum sinomontanum Nakai in Gansu province in China. The structures were elucidated by IR,NMR, Anal. and X-ray diffraction analysis. Crystal data: C₃₂H₄₇ClN₂O₉, M_r = 639.17, space group monoclinic, P2₁; a=10.665 (7) Å, b=12.178 (7) Å and c=12.214 (7) Å; β=91.003 (10)°, Z=2, D_x = 1.338 mg/m^-3, F(000)= 684, µ=0.18.00 mm^-1, V=1586.1 (16) Å³; R₁=0.038, wR₂=0.087, Flack parameter x= -0.12 (7). Ring A, B, C, D, E and F respectively present boat, chair, envelope, boat, boat and envelope forms. The absolute configuration was determined as 1S, 4S, 5S, 7S, 8S, 9S, 10S, 11S, 13R, 14S, 16S, 17 R. And the analgesic potential has been investigated in a mouse model of acute pain. The result exhibited that the analgesic effect of the compound is worse than lappaconitine hydrobromide.

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Periodical:

Advanced Materials Research (Volumes 343-344)

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1049-1052

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.343-344.1049

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September 2011

Authors:

Wen Xiu Sun, Tun Galag Dong, Chun Ming Ding

Keywords:

Antinociceptive Properties, Lappaconitine, Lappaconitine Hydrochloride, Single Crystal

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