Crystal Structure Analysis and Antinociceptive Property of Lappaconitine Hydrochloride

Abstract:

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An alkaloid compound, lappaconitine Hydrochloride, was synthesized with lappaconitine which was isolated from the root of Aconitum sinomontanum Nakai in Gansu province in China. The structures were elucidated by IR, NMR, Anal. and X-ray diffraction analysis. Crystal data: C32H47ClN2O9, Mr = 639.17, space group monoclinic, P21; a=10.665 (7) Å, b=12.178 (7) Å and c=12.214 (7) Å; β=91.003 (10)°, Z=2, Dx = 1.338 mg/m-3, F(000)= 684, µ=0.18.00 mm-1, V=1586.1 (16) Å3; R1=0.038, wR2=0.087, Flack parameter x= -0.12 (7). Ring A, B, C, D, E and F respectively present boat, chair, envelope, boat, boat and envelope forms. The absolute configuration was determined as 1S, 4S, 5S, 7S, 8S, 9S, 10S, 11S, 13R, 14S, 16S, 17 R. And the analgesic potential has been investigated in a mouse model of acute pain. The result exhibited that the analgesic effect of the compound is worse than lappaconitine hydrobromide.

Info:

Periodical:

Advanced Materials Research (Volumes 343-344)

Edited by:

David Wang

Pages:

1049-1052

DOI:

10.4028/www.scientific.net/AMR.343-344.1049

Citation:

W. X. Sun et al., "Crystal Structure Analysis and Antinociceptive Property of Lappaconitine Hydrochloride", Advanced Materials Research, Vols. 343-344, pp. 1049-1052, 2012

Online since:

September 2011

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$35.00

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