EUK1111 Attenuates Scopolamine-Induced Learning Deficits in the Passive Avoidance Test

Abstract:

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The aim of the experiment was to investigate the effects of the EUK1111 on passive avoidance of amnestic mice model induced by scopolamine. Five groups were divided: Control, model, model + high concentration (260 mg/kg), model + middle concentration (104.2 mg/kg) and model + low concentration (5.2 mg/kg). An open field experiment was conducted to test the locomotor activity after EUK1111 was taken orally 30 days. Scopolamine was injected intraperitoneal (1.5 mg/kg ) 10 minutes before passive avoidance test was conducted. There were no significant difference among the groups on move time, total moves, move velocity and move distance (P > 0. 05). However, in passive avoidance test, the latencies to dark side were significantly longer in model + high concentration group, model + middle concentration group than model group ( P < 0. 05). It indicates that EUK1111 may attenuate scopolamine induced learning deficits.

Info:

Periodical:

Edited by:

J.L. Zhong

Pages:

276-279

DOI:

10.4028/www.scientific.net/AMR.345.276

Citation:

Q. W. Zeng et al., "EUK1111 Attenuates Scopolamine-Induced Learning Deficits in the Passive Avoidance Test", Advanced Materials Research, Vol. 345, pp. 276-279, 2012

Online since:

September 2011

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$35.00

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