EUK1111 Attenuates Scopolamine-Induced Learning Deficits in the Passive Avoidance Test
The aim of the experiment was to investigate the effects of the EUK1111 on passive avoidance of amnestic mice model induced by scopolamine. Five groups were divided: Control, model, model + high concentration (260 mg/kg), model + middle concentration (104.2 mg/kg) and model + low concentration (5.2 mg/kg). An open field experiment was conducted to test the locomotor activity after EUK1111 was taken orally 30 days. Scopolamine was injected intraperitoneal (1.5 mg/kg ) 10 minutes before passive avoidance test was conducted. There were no significant difference among the groups on move time, total moves, move velocity and move distance (P > 0. 05). However, in passive avoidance test, the latencies to dark side were significantly longer in model + high concentration group, model + middle concentration group than model group ( P < 0. 05). It indicates that EUK1111 may attenuate scopolamine induced learning deficits.
Q. W. Zeng et al., "EUK1111 Attenuates Scopolamine-Induced Learning Deficits in the Passive Avoidance Test", Advanced Materials Research, Vol. 345, pp. 276-279, 2012