EUK1111 Attenuates Scopolamine-Induced Learning Deficits in the Passive Avoidance Test

Qing Wen Zeng; Ya Le Duan; Xiao Hua Cao; Bai Rui Tao

doi:10.4028/www.scientific.net/AMR.345.276

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 345EUK1111 Attenuates Scopolamine-Induced Learning...

EUK1111 Attenuates Scopolamine-Induced Learning Deficits in the Passive Avoidance Test

Abstract:

The aim of the experiment was to investigate the effects of the EUK1111 on passive avoidance of amnestic mice model induced by scopolamine. Five groups were divided: Control, model, model + high concentration (260 mg/kg), model + middle concentration (104.2 mg/kg) and model + low concentration (5.2 mg/kg). An open field experiment was conducted to test the locomotor activity after EUK1111 was taken orally 30 days. Scopolamine was injected intraperitoneal (1.5 mg/kg ) 10 minutes before passive avoidance test was conducted. There were no significant difference among the groups on move time, total moves, move velocity and move distance (P > 0. 05). However, in passive avoidance test, the latencies to dark side were significantly longer in model + high concentration group, model + middle concentration group than model group ( P < 0. 05). It indicates that EUK1111 may attenuate scopolamine induced learning deficits.

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Periodical:

Advanced Materials Research (Volume 345)

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276-279

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https://doi.org/10.4028/www.scientific.net/AMR.345.276

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September 2011

Authors:

Qing Wen Zeng, Ya Le Duan, Xiao Hua Cao, Bai Rui Tao

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EUK1111, Passive Avoidance, Scopolamine

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