In this paper, with the ANSYS, stress distribution, safety factor and fatigue life cycle of high-pressure common rail diesel engine connecting rod were analyzed by using 3D finite element method. The results show that the position of maximum principal stress is transition location of small end and connecting rod shank at maximum compression condition. The value of stress is 253.98 MPa in dangerous position. Safety factor is 2.67. The position of maximum principal stress is medial surface of small end at maximum stretch condition. The value of stress is 87.199 MPa in dangerous position. The fatigue life cycle of connecting rod is 2.6812×108. Fatigue safety factor is 1.5264.