Phytoalcca acinosa Roxb, a perennial and herb, was reported to be a Mn-hyperaccumulator. In this study, P. acinosa was investigated for its potential to remove Mn from the soil in a series of pot experiments. The results showed that P. acinosa had a high extraction capacity for manganese in soil and extracted manganese from soil to the leaves and stems quickly. The average concentration of Mn in leaves was 17,043 mg/kg dry weight (DW) with a maximum of 28,202mg/kg DW. While the average Mn concentration in stems and roots were 3,138 mg / kg DW and 2,189 mg / kg DW respectively, and were less than those in leaves. Amount of Mn extracted by a plant was the highest (13.000 mg/plant) when Mn concentration was 500mg/kg DW in soil. Dynamic experiment indicated the best harvest time for P. acinosa was 60d. The sequential harvests did not significantly affect Mn accumulation and shoot biomass (p > 0.05), however, the stem and leave biomass were changed (p<0.05), indicating that sequential harvest might be an available and convenient way to achieve the decontamination of Mn-contaminated soils by P. acinosa. These results showed that P. acinosa with a high capacity to remove manganese from soil might be a good candidate for remediation of Mn-contaminated soils.