Synthesis and Purification of L-Phenylalanine Oligo-Peptides Assisted by Phosphorus Oxychloride

Ming Xiu Lv; Li Ming Qiang; Kui Lu; Ying Yan Yao

doi:10.4028/www.scientific.net/AMR.365.150

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 365Synthesis and Purification of L-Phenylalanine...

Synthesis and Purification of L-Phenylalanine Oligo-Peptides Assisted by Phosphorus Oxychloride

Abstract:

Oligo-peptides have been focused on by chemists recently because of the strong bioactivity an activity as drug or precursor of drug. α-Amino acid could self-assemble into oligo-peptides with the assistance of inorganic phosphorus reagents, so it could provide a new method to synthesize peptides. In this paper, the self-assembly reaction of L-Phenylalanine mediated by phosphorus oxychloride were studied by using ESI-MS. The proper condition of self-assembly reaction of L-Phe was reported. The reaction products were purified by RP-HPLC and Phe-Phe dipeptide was characterized by the means of IR, ¹H-NMR, ¹³C-NMR and ESI-MS/MS.

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Periodical:

Advanced Materials Research (Volume 365)

Pages:

150-154

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.365.150

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Online since:

October 2011

Authors:

Ming Xiu Lv, Li Ming Qiang, Kui Lu, Ying Yan Yao

Keywords:

Dipeptide, ESI-MS, High Performance Liquid Chromatography (HPLC), L-Phenylalanine, Phosphorus Oxychloride

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