Synthesis and Purification of L-Phenylalanine Oligo-Peptides Assisted by Phosphorus Oxychloride

Abstract:

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Oligo-peptides have been focused on by chemists recently because of the strong bioactivity an activity as drug or precursor of drug. α-Amino acid could self-assemble into oligo-peptides with the assistance of inorganic phosphorus reagents, so it could provide a new method to synthesize peptides. In this paper, the self-assembly reaction of L-Phenylalanine mediated by phosphorus oxychloride were studied by using ESI-MS. The proper condition of self-assembly reaction of L-Phe was reported. The reaction products were purified by RP-HPLC and Phe-Phe dipeptide was characterized by the means of IR, 1H-NMR, 13C-NMR and ESI-MS/MS.

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Periodical:

Edited by:

Barry Tan

Pages:

150-154

DOI:

10.4028/www.scientific.net/AMR.365.150

Citation:

M. X. Lv et al., "Synthesis and Purification of L-Phenylalanine Oligo-Peptides Assisted by Phosphorus Oxychloride", Advanced Materials Research, Vol. 365, pp. 150-154, 2012

Online since:

October 2011

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$35.00

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