In this paper, a real high-piers bridge was taken as the example, the 3D nonlinear finite element model of this high-pier bridge is built based on OpenSees, then to do the analysis of seismic collision effects of the high-pier bridge under uniform excitation and multi-excitation considering the effect of traveling wave. And analyzing the reaction rule under different ground motions, and focusing on the differences of the effects of seismic pounding between uniform excitation and multi-excitation considering the effect of traveling wave. the seismic responses of high-pier bridge are closely related with its inherent dynamic characteristics and the spectral characteristics of ground motion and closer to the natural cycle of the bridge the main periods of ground motion is,greater the bridge collision response; traveling wave effect amplifies seismic pounding response, while the end of piers are adversely affected, exacerbating the damage. Although whether or not the traveling wave effect is harmful to the bearing, the traveling wave effect has obvious influences to bearing. Therefore, in the analysis of bridge seismic collision response it is necessary to consider traveling wave effect.