Predict Interactions between Protein Residues for Developing Antibody Therapeutics

Wen Lung Shu; Chia Hsuan Lee

doi:10.4028/www.scientific.net/AMR.383-390.4003

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 383-390Predict Interactions between Protein Residues for...

Predict Interactions between Protein Residues for Developing Antibody Therapeutics

Abstract:

Recently, protein-antibody therapeutics becomes a hot search topic. In this paper, all protein interaction data files are collected from INTERPARE. Protein sequence and its secondary structure both are used to build HMM mathematical model. We randomly take 80% data to train positive and negative HMM models and 20% data to test. The accuracy of this approach can reach to 79.80%. This model can further be used to predict protein function sites and predict if a protein interacts with other proteins.

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Manufacturing Science and Technology, ICMST2011

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Periodical:

Advanced Materials Research (Volumes 383-390)

Pages:

4003-4006

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.383-390.4003

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Online since:

November 2011

Authors:

Wen Lung Shu, Chia Hsuan Lee

Keywords:

Antibody Therapeutics, HMM, Predict Protein Interactions, Protein 1D and 2D Sequence, Protein 3D Structure

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