Study on Generation of Digital Micro-Fluids Based on Surface Acoustic Wave

Abstract:

The generation of digital micro-fluid is indispensable operation unit for lab-on-a-piezoelectric-substrate. A new generation method of digital micro-fluid is proposed in this paper. An interdigital transducer (IDT) and a reflector were fabricated on 1280 YX-LiNbO3 substrate, which was used to excited surface acoustic wave. A needle with 400um inside diameter connected with a syringe was on the piezoelectric substrate, of which space could be adjusted. The needle tip and the piezoelectric substrate were coated with Teflon AF 1600. Water was used to generate digital micro-fluid experiments due to most samples or reagents being water solution. Experimental results show that the volumes of generated digital micro-fluid are relied on the space between the needle tip and the piezoelectric substrate, contact angle of the needle tip and RF power acted on the IDT. When the flow velocity of the syringe being 2.269 mm/min, space between the needle tip and the substrate being 0.98mm and 34mdB RF signal power, the volume of the generated water digital micro-fluid is 2ul. Change the space and RF signal power, the volume of generated water digital micro-fluid is also different. The method of generating digital micro-fluid can be greatly useful for Lab-on-a-piezoelelctric-chips.

• Periodical: Advanced Materials Research (Volumes 383-390)
• Pages: 5100-5105
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.383-390.5100
• Online since: November 2011
• Authors: Yi Qing Wei, An Liang Zhang
• Keywords: Digital Micro-Fluid, Generation, Piezoelectric Substrate, Surface Acoustic Wave (SAW)

References

[1] Mina Okochi, Hiroyoshi Tsuchiya, Fumitaka Kumazawa, Mitsuhiro Shikida, Hiroyuki Honda, Droplet-based gene expression analysis using a device with magnetic force-based-droplet-handling system [J], Journal of Bioscience and Bioengineering, 2010, 109(2), P193-197.

DOI: 10.1016/j.jbiosc.2009.07.005

[2] Séverine Le Gac, Albert van den Berg, Single cells as experimentation units in lab-on-a-chip devices [J], Trends in Biotechnology, 2010, 28 (2), P55-62.

DOI: 10.1016/j.tibtech.2009.10.005

[3] R. Dreyfus, P. Tabeling and H. Willaime, Ordered and disordered patterns in two-phase flows in microchannels [J], Phys. Rev. Lett. 2003, 90(14), P144505-1-4.

DOI: 10.1103/physrevlett.90.144505

[4] P. Garstecki, I. Gitlin, W. GiLuzio, G. M. Whitesides, Formation of monodisperse bubbles in a microfluidic flow-focusing device[J], Appied . Physics . Leters, 2004, 85(13), P2649-2651.

DOI: 10.1063/1.1796526

[5] Takuya Harada, Naoyuki Ishikawa, Takefumi Kanda, Droplet generation using a torsional Langevin-type transducer and a micropore plate[J], Sensors and Actuators A: Physical, 2009, 155(1), P168–174.

DOI: 10.1016/j.sna.2009.08.007

[6] Chuang-Yuan Lee, Hongyu Yu and Eun Sok Kim, Droplet-based microreactions with oil encapsulation [J], Journal of microelectromechanical systems, 2008, 17(1), P147-156.

DOI: 10.1109/memsys.2007.4433019

[7] Séverine Le Gac, Albert van den Berg, Single cells as experimentation units in lab-on-a-chip devices [J], Trends in Biotechnology, 2010, 28 (2), P55-62.

DOI: 10.1016/j.tibtech.2009.10.005

[8] Lucia granieri, Jean-Christophe Baret, High-throughout screening of enzymes by retroviral display using droplet-based microfluidics [J], Chemistry &Biology, 2010, 17(3), P229-235.

DOI: 10.1016/j.chembiol.2010.02.011

[9] Chun-Guang Yang, Zhang-Run Xu, Jian-Hua Wang, Manipulation of droplets in microfluidic systems[J], TrAC Trends in Analytical Chemistry, 2010, 29(2), P141-157.

DOI: 10.1016/j.trac.2009.11.002

[10] Yung-Chieh Tan, Vittorio Cristini, Abrahamp. Lee, Monodispersed microfluidic droplet generation by shear focusing microfluidic device[J], Sensors and Actuators B: Chemical, 2006, 114(1), P350-356.

DOI: 10.1016/j.snb.2005.06.008

[11] M.J. Schertzer, R. Ben-Mrad P.E. Sullivan, Using capacitance measurements in EWOD devices to identify fluid composition and control droplet mixing[J], Sensors and Actuators B: Chemical, 2010, 145(1), P340-347.

DOI: 10.1016/j.snb.2009.12.019

[12] Alan Renaudin Jean-Pierre Sozanski, Bemard Verbeke, Monitoring SAW-actuated microdroplets in view of biological applications [J]. Sensors and Actuators B: Chemical, 2009, 138(1), P374-382.

DOI: 10.1016/j.snb.2009.02.031

[13] T. K. Uchida, T. Suzuki and S. Shiokawa, Investigation of acoustic streaming excited by surface acoustic waves[C], IEEE Ultrasonics symposium, New York, USA, Nov. 7-10, (1995).

DOI: 10.1109/ultsym.1995.495749

[14] S. Shiokawa, Y. Matsui and T. Ueda, Liguid streaming and droplet formation caused by leaky Rayleigh wave[C], IEEE Ultrasonics symposium, New York, USA, Oct. 3-6, (1989).

DOI: 10.1109/ultsym.1989.67063