The Generation of Droplets with Micro-Liter Volume Using Surface Acoustic Wave

An Liang Zhang; Qin Jiang Han

doi:10.4028/www.scientific.net/AMR.383-390.5106

Paper Titles

Twelve-Position Calibrating Method without North Using for Three-Axis Magnetic Sensor
p.5082

Study on SRUKF Applied in Initial Alignment with Large Misalignment Angle on Stationary Base of SINS
p.5088

Fault Monitoring of Transformer Based on FTIR
p.5094

Study on Generation of Digital Micro-Fluids Based on Surface Acoustic Wave
p.5100

The Generation of Droplets with Micro-Liter Volume Using Surface Acoustic Wave
p.5106

Low Bit Rate Speech Coding Using Lattice Vector Quantization and Time-Scale Modification
p.5111

Two-Dimensional Body Untouched Measurement System Research and Developing-Based on Sunplus SPCE3200
p.5117

The Design of DC Motor Excitation Regulation System Based on DSP
p.5123

A Simulation Software of Critical Sour Well Blowout Based on FLUENT
p.5130

HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 383-390The Generation of Droplets with Micro-Liter Volume...

The Generation of Droplets with Micro-Liter Volume Using Surface Acoustic Wave

Abstract:

We developed a digital micro-fluid generator for the discrete dispensing of bio-samples into a bio-analytical unit on piezoelectric substrate. This micro-fluid device is comprised of a micro-channel, a step and a 1280 yx-LiNbO3 substrate. An ejector jet pump is used for offering a uniform linear velocity. After formed micro-fluid from micro-channel arrives the step, it will be down to the piezoelectric substrate due to its gravity and will be transported by surface acoustic wave (SAW). The micro-fluid generator can generate mono-disperse digital micro-fluid of micro-liter volume relied on the gap between micro-channel and the step. The generation time of digital micro-fluid is about several seconds time, which is also relation to the gap. And the digital micro-fluid generation is repeatable and stable with a typical variation of less than 7% of digital micro-fluid volume. Our digital micro-fluid generator can be effectively applied to biochemical analysis on a piezoelectric substrate.

You might also be interested in these eBooks

Manufacturing Science and Technology, ICMST2011

View Preview

Info:

Periodical:

Advanced Materials Research (Volumes 383-390)

Pages:

5106-5110

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.383-390.5106

Citation:

Cite this paper

Online since:

November 2011

Authors:

An Liang Zhang, Qin Jiang Han

Keywords:

Digital Micro-Fluid, Generation, Lab on a Piezo-Electirc Chip, Surface Acoustic Wave (SAW)

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

References

[1] D. N. Kim, Y. l Lee W.G. Koh, Fabrication of microfluidic devices incorporating bead-based reaction and microarray-based detection system for enzymatic assay [J], Sens. Actuators B Chem., 2009, 137 (1), P305–312.

DOI: 10.1016/j.snb.2008.12.042

Google Scholar

[2] S.L. Lonigro, F. Valerio, M.D. Angelis, P.D. Bellis, P. Lavermicocca, Microfluidic technology applied to cell-wall protein analysis of olive related lactic acid bacteria [J], Itl J. Food Microbi. 2009, 130 (1), P6–11.

DOI: 10.1016/j.ijfoodmicro.2008.12.018

Google Scholar

[3] T. H. Fang, N. Ramalingam, X.D. Dong, T. S. Ngin, X.T. Zeng, Real-time PCR microfluidic devices with concurrent electrochemical detection [J], Biosens. Bioelectron., 2009, 24 (7), P2131–213.

Google Scholar

[4] P F. B. Myers and L. P. Lee, Innovations in optical microfluidic technologies for point-of-care diagnostics [J], Lab Chip, 2008, 8 (12), P2015-(2031).

DOI: 10.1039/b812343h

Google Scholar

[5] X. Weng, C. H. Chon , H. Jiang , D.Q. Li, Rapid detection of formaldehyde concentration in food on a polydimethylsiloxane (PDMS) microfluidic chip [J], 2009, Food Chem., 114 (3), 1079–1082.

DOI: 10.1016/j.foodchem.2008.10.027

Google Scholar

[6] R. Malk,Y. Fouillet, L. Davoust, Rotating flow within a droplet actuated with AC EWOD [J], Procedia chemistry, 1(1)1107-1110.

DOI: 10.1016/j.proche.2009.07.276

Google Scholar

[7] Chun-guang, Zhang-Run Xu, Jian-Hua Wang, Manipulation of droplets in microfluidic systems [J], Trends in analytical chemistry, 2010, 29(2), P141-157.

Google Scholar

[8] Amelia L. Markey, Stephan Mohr, Philip J.R. Day, High-throughput droplet PCR [J], Methods, 2010, 50(4), P277-281.

DOI: 10.1016/j.ymeth.2010.01.030

Google Scholar

[9] T. Thorsen, R.W. Roberts, F.H. Arnold, S.R. Quake, Dynamic pattern formation in a vesicle-generating microfluidic device [J], Phys. Rev. Lett. , 2001, 86(18), P4163-4166.

DOI: 10.1103/physrevlett.86.4163

Google Scholar

[10] Yung-Chieh Tan, Vittorio Cristini, and Abraham P. Lee, Monodispersed microfluidic droplet generation by shear focusing microfluidic device [J], Sensors and Actuators B , 2006, 114(1), P350-356.

DOI: 10.1016/j.snb.2005.06.008

Google Scholar

[11] Zhi Wen Tan, Su Gui Gisela Teo and Junhui Hu, Ultrasonic generation and rotation of a small droplet at the tip of a hypodermic needle [J], Journal of applied physics , 2008, 104(10), P104902-1-5.

DOI: 10.1063/1.3021099

Google Scholar

[12] Alan Renaudin Jean-Pierre Sozanski, Bemard Verbeke, Monitoring SAW-actuated microdroplets in view of biological applications[J]. Sensors and Actuators B: Chemical, 2009, 138(1), P374-382.

DOI: 10.1016/j.snb.2009.02.031

Google Scholar

[13] T. K. Uchida, T. Suzuki and S. Shiokawa, Investigation of acoustic streaming excited by surface acoustic waves[C], IEEE Ultrasonics symposium, New York, USA, Nov. 7-10, (1995).

DOI: 10.1109/ultsym.1995.495749

Google Scholar

[14] S. Shiokawa,Y. Matsui and T. Ueda, Liguid streaming and droplet formation caused by leaky Rayleigh wave[C], IEEE Ultrasonics symposium, New York, USA, Oct. 3-6, (1989).

DOI: 10.1109/ultsym.1989.67063

Google Scholar