Strontium Modification of Biomaterial: The Effective Approach to Enhance the Bioactivity and Biocompatibility of Calcium Silicate

Abstract:

Calcium silicate (CS), the recent developed biodegradable ceramic, shows potential in stimulating bone regeneration. However, the rapid degradation restricts its further application, that is, the cytotoxicity is highly suspicious. In this study, the attempt with the addition of strontium by partially replacing the site of calcium shows appropriate, not only enhancing the bioactivity of CS, but also promoting its biocompatibility. Thus, the modification of biomaterial by strontium seems to be an effective approach for biological application.

• Periodical: Advanced Materials Research (Volumes 391-392)
• Pages: 195-199
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.391-392.195
• Online since: December 2011
• Authors: Wei Bin Zhang, Wai Ching Liu, Wei Ming Gu, Lei Chen, Yu Hui Shen
• Keywords: Bioactivity, Biocompatibility, Calcium Silicate, Strontium

References

[1] W.C. Xue, A. Bandyopadhyay, S. Bose. Mesoporous calcium silicate for controlled release of bovine serum albumin protein. Acta Biomater Vol 5 (2009), p.1686–1696.

DOI: 10.1016/j.actbio.2009.01.012

[2] S. Xu, K. Lin, Z. Wang, J. Chang, L. Wang, J. Lu. Recon- struction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics. Biomaterials Vol 29 (2008), p.2588–2596.

DOI: 10.1016/j.biomaterials.2008.03.013

[3] J. Buehler, P. Chappuis, J.L. Saffar, Y. Tsouderos, A. Vignery. Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis). Bone, Vol 29 (2001), p.176–179.

DOI: 10.1016/s8756-3282(01)00484-7

[4] Z.Y. Li, W.W. Lu, P.K.Y. Chiu, W.M. Lam, B. Xu, K. M. C. Cheung, J. C. Y. Leong, K. D. K. Luk. Strontium-calcium coadminis- tration stimulates bone matrix osteogenic factor expression and new bone formation in a large animal model. J. Orthop. Res. Vol 27 (2010).

DOI: 10.1002/jor.20818

[5] S. Peng, G. Zhou, K. D. K. Luk, K. M. C. Cheung, Z. Y. Li, W. M. Lam, Z. Zhou, W. W. Lu. Strontium promotes osteogenic differentiation of mesenchymal stem cells through the Ras/MAPK signaling pathway. Cell. Physiol. Biochem. Vol 23(2009).

DOI: 10.1159/000204105

[6] J. Y. Reginster. Strontium ranelate in the therapeutic strategies for osteoporosis, including GIO. Bone Vol 45(2009), p. S131.

DOI: 10.1016/j.bone.2009.07.042

[7] N. A. T. Hamdy. Strontium ranelate improves bone micro architecture in osteoporosis. Rheumatology Vol 48 (2009), p. Iv9–Iv13.

DOI: 10.1093/rheumatology/kep274

[8] B. Habermann, K. Kafchitsas, G. Olender, P. Augat, A. Kurth. Strontium ranelate enhances callus strength more than PTH 1-34 in an osteoporotic rat model of fracture healing. Calcif. Tissue Int. Vol 86 (2010), p.82–89.

DOI: 10.1007/s00223-009-9317-8

[9] C.T. Wu, Y. Ramaswamy, D. Kwik, H. Zreiqat. The effect of strontium incorporation into CaSiO3 ceramics on their physical and biological properties. Biomaterials Vol 28 (2007), p.3171–3181.

DOI: 10.1016/j.biomaterials.2007.04.002

[10] L. L. Hench, J.M. Polak. Third-generation biomedical materials. Science 2002, Vol 295 (2002), p.1014–1017.

DOI: 10.1126/science.1067404

[11] W. Zhang, Y. Shen , H. Pan, K. Lin, X. Liu, B.W. Darvell, W.W. Lu, J. Chang, L. Deng, D. Wang, W. Huang. Effects of strontium in modified biomaterials. Acta Biomater. Vol 7(2011), pp.800-888.

DOI: 10.1016/j.actbio.2010.08.031