Disulfide Cross-Linked Hydrogel Scaffold Based on Poly (Amic Acid) with Tunable Degradation

Jiao Xia Sun; Yuan Liang Wang; Chang Shun Ruan; Shu Hua Dou

doi:10.4028/www.scientific.net/AMR.391-392.319

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 391-392Disulfide Cross-Linked Hydrogel Scaffold Based on...

Disulfide Cross-Linked Hydrogel Scaffold Based on Poly (Amic Acid) with Tunable Degradation

Abstract:

The objective of this work was to create 3D hydrogel with tunable degradability for use in tissue regeneration. Therefore, we reported the synthesis and characterization of a novel degradable hydrogel based on poly (amic acid) (PAA). Unlike previously reported degradable hydrogel, these materials contained two kind of cleavable bonds to adjust their degradation. FTIR was employed to characterize the structure of PAA and hydrogels. Swelling ratio and degradation time correlated with the molar ratio of two cross-linkers and cross-linked density. The surface microstructure of hydrogels during degradation was observed by SEM. These properties changed predictably as degradation.

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Periodical:

Advanced Materials Research (Volumes 391-392)

Pages:

319-322

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.391-392.319

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Online since:

December 2011

Authors:

Jiao Xia Sun, Yuan Liang Wang, Chang Shun Ruan, Shu Hua Dou

Keywords:

Degradation, Disulfide Cross-Linked, Hydrogel, Poly(amic acid)

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