Experimental Investigation on the Lipid-Lowering Activity of Three Novel Antilipidemic Materials In Vitro

Abstract:

Chitosan is a new kind of material in life-science, it can be used in lipid-lowering. Chitosan microspheres (CTS-MP) were prepared by spray-drying, chitosan nanoparticles (CTS-NP) and chitosan-capsaicin microspheres (CTS-CAP-MP) were prepared by ionic gelation process. The effect of these samples on lowering lipids was evaluated by measuring its’ binding capacities with lipids under the conditions mimicking the gastrointestinal tract in vitro. Also, the particle sizes of chitosan preparations were examined by scanning electron microscopy (SEM) and particle size analyzer. The results showed that the lipids-binding capacities of CTS-MP and CTS-NP were far more higher than that of CTS and CTS-CAP-MP. In conclusion, CTS-MP and CTS-NP will be better fat-lowing food additives to replace chitosan. The mechanism of lipids-binding in vitro is not only physical adsorption. Particle size is not the determinant factor, electrostatic action is maybe another factor of lipids-binding.

• Periodical: Advanced Materials Research (Volumes 399-401)
• Pages: 1568-1572
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.399-401.1568
• Online since: November 2011
• Authors: Si Rong Tan, Si Hui Wu, Bing Gao, Jun Rui Xiao, Zi Yue Guo, Si Yun Long, Yan Bai, Zheng Quan Su
• Keywords: Capsaicin, Chitosan (CS), Chitosan Microspheres, Chitosan Nanoparticles, Lipids-Lowering

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