Polysaccharides Grafting on Fluorocarbon Films Deposited by Plasma on 316L Stainless Steel for Long Term Stable Stent

Abstract:

Metallic intravascular stents are medical scaffolds commonly used to heal diseased arteries and to restore blood flow in vessels after a balloon angioplasty. Although clinical complications occurs (mainly in-stent-restenosis, representing 30-40% of cases within six months after angioplasty), this clinical procedure reduces the risk of restenosis. In order to improve the long-term clinical performances of stents, different coatings, bioactives or not, are investigated. However, the adhesion of the coating within the substrate is often weak and delamination after stent deployment could be observed. Therefore, our approach was to consider a plasma fluorocarbon film deposit on stainless steel substrates, improving adhesion and providing protection against the stent corrosion, as a carrier for the subsequent grafting of a polysaccharide (dextran). Indeed, a copolymer made of dextran and metacrylate has already demonstrated interesting results toward cell proliferation and appropriate mechanical properties regarding stent deployment. Hence, the aim of this project is to covalently graft the copolymer of dextran-methacrylate to plasma-aminated fluorocarbon film. In this study, dextrans were functionalized in order to conjugate them to amino groups. Two different ways of functionalization were investigated: by carboxylmethylation reaction and by periodate oxidation. Characterizations were performed by FTIR, for organic syntheses and by XPS for the subsequent grafting on the surface. Coatings topography and stability were also investigated. Preliminary results suggest the use of polysaccharides grafted by plasma on fluorocarbon films to provide a stable stent surface.

• Periodical: Advanced Materials Research (Volume 409)
• Pages: 164-169
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.409.164
• Online since: November 2011
• Authors: Eléonore Michel, P. Chevallier, Amélie Barrère, Didier Letourneur, Diego Mantovani
• Keywords: Carboxymethyl Dextran, Fluorocarbon Film, Grafting, Oxidized Dextran, Polysaccharide

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