Modulation of Behaviours of Cultured Cells on Polycaprolactone/Chitosan Blended Biomaterials

Abstract:

Our previous study has illustrated that chitosan could enhance human anterior cruciate ligament cells to exhibit a dramatic effect on increasing the gene expression of transforming growth factor β1, which is a specific gene for wound healing and collagen synthesis. However, most of cells could not adhere and proliferate well on chitosan. In order to overcome this drawback, we introduced polycaprolactone (PCL) into chitosan by the method of blending in this study. It was found that the morphology, viability and gene expression of specific cells on the chitosan/PCL blended materials could be effectively regulated. Therefore, it is possible to combine the advantages of chitosan and PCL to create a new blended material, which could control cellular morphologies specifically, and further to regulate the gene expression and protein production of cells for specific applications.

• Periodical: Advanced Materials Research (Volume 410)
• Pages: 79-80
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.410.79
• Online since: November 2011
• Authors: Tai Horng Young
• Keywords: Blending, Chitosan, Co-Culture, PCL

References

[1] H.J. Shao, Y.T. Lee, C.S. Chen, J.H. Wang, T.H. Young: Biomaterials Vol. 31 (2010) p.4695.