The Antioxidant Resveratrol from Polygonum Cuspidatum Reverses Memory Impairment and Brain Oxidative Stress in SAMP8 Mice

Abstract:

Resveratrol (RVT) is a phytoalexin polyphenolic compound found in various plants, including grapes, berries and peanuts. Recently, studies have documented various health benefits of resveratrol including cardiovascular and cancer-chemopreventive properties. The aim of the present study was to demonstrate the effects of resveratrol on the learning and memory impairment. The senescence-accelerated mice (SAM) were introgastric gavage administrated resveratrol (25,100mg/(kg•bw)) for 60 days. The learning and memory behavior was assessed using open-field test while the parameters of oxidative stress assessed were malondialdehyde (MDA) and superoxide dismutases (SOD).The results showed that resveratrol significantly improved the learning and memory ability in open-field test. Further investigation showed that resveratrol restored SOD levels, but decreased MDA level in the mouce brain. These results indicated that the pharmacological action of RVT may offer a novel therapeutic strategy for the treatment of age-related conditions.

• Periodical: Advanced Materials Research (Volume 422)
• Pages: 470-473
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.422.470
• Online since: December 2011
• Authors: Gui Shan Liu, Ze Sheng Zhang, Bo Yang, Wei He
• Keywords: Learning and Memory Impairment, Malondialdehyde (MDA), Open-Field Test, Oxidative Stress, Resveratrol, SOD

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