Traditional Chinese Medicine Epimedium Release from PLGA/HA Scaffolds Prepared in Supercritical CO₂

Abstract:

Traditional chinese medicine epimedium was introduced into the poly(D,L-lactide-co-glycolide) / hydroxyapatite (PLGA/HA) scaffolds by using a supercritical CO2 technique. The morphology, porosity, mechanical strength, degradation behaviors, and drug release kenitics of scaffolds with 1wt%, 5 wt% and 10 wt% of epimedium were determined. The results revealed that the micropores and macropores in the scaffolds were interconnect, and the addition of drug had little effect on the morphology of scaffolds. When the drug was at 10 wt% , the porosity and mechnical strength of scaffolds were deteriorated. The dosage of epimedium in scaffolds exhibits an signficant influence on weight loss of scaffolds and release kenitics of epimedium. Within the limits of our study, 5 wt% epimedium loaded scaffolds might be suitable for bone tissue egineering application.

• Periodical: Advanced Materials Research (Volumes 424-425)
• Pages: 48-51
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.424-425.48
• Online since: January 2012
• Authors: Jin Song Liu, Li Hua Xu, Zhen Nan Deng, Si Qian Wang, Xiao Li Ji
• Keywords: Drug Release, Epimedium, Scaffold, Tissue Engineering

References

[1] B. Stevens, Y. Yang, A. Mohandas, B. Stucker, K.T. Nguyen, J. Biomed. Mater. Res. (Appl Biomater.), 85B(2008), p.573.

[2] T.A. Holland, A.G. Mikos, Adv. Biochem. Eng. Biotechnol., 102(2006), p.161.

[3] L. Zhou, L. Cui, T.Wu, Chinese. J. Osteoporosis., 14(2008), p.90.

[4] J.Q.Ma, X.Q.Ma, X.Y. Zhang, Chinese. J. New. Drugs., 18(2009), p.553.

[5] L.D. Harris, B.S. Kim, D.J. Mooney, J. Biomed. Mater. Res., 42(1998), p.396.

[6] X.H. Zhu, L.Y. Lee, J.S. Jackson, Y.W. Tong, Biotechnol. Bioeng., 100(2008), p.998.

[7] I. Tsivintzelis, E. Pavlidou, C. Panayiotou, J. Supercritical. Fluids., 42(2007), P. 265.

[8] X.X. Wang, w. Li, V. Kumar, biomterials., 27(2006), p.1924.

[9] Y.H. Gong, Q.L. Zhou, C.Y. Gao, J.C. Shen, Acta. Biomater., 3(2007), p.531 .

[10] M.Vert, J. Mauduit, S.M. Li, Biomaterials., 15(1994), p.1209.