Optimized Formula with Linear Programming Model for Anticancer Production of Marine Fungus

Abstract:

In order to promote the yield of anticancer chemical compound PJ157 of marine YUP08 strain, the Linear Programming model (LP model) was used to optimize four components of medium for the strain. The primary culture medium consists of glucose, peptone, yeast and NaCl, which were possessory worked on growing and metabolism of the fungus. Contribution rate from data was built to manage complex effects for produce PJ157. It is forecast that the yield of PJ157 could be increased to 0.21735 mg/L which was great more than 0.04 mg/L in the before. Therefore the LP model could be used for fermentation optimization of microorganism.

• Periodical: Advanced Materials Research (Volumes 433-440)
• Pages: 992-994
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.433-440.992
• Online since: January 2012
• Authors: Tian Wang, Lin Wang, Li Tian
• Keywords: Anticancer Production, LP Model, Marine Fungus

References

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[7] M. H. Hansen and Y. Bin, Model selection and the principle of minimum description length, J. Amer. Statist. Assoc., vol. 96, No. 454, 2001. TABLE III. THE FIGURES FROM EIGHT BIOLOGICAL EXPERIMENTS Glucose concentration Peptone concentration NaCl Yeast extraction concentration PJ157 1 15 mg/L 5 mg/L.

5 mg/L 3 mg/L.

03 mg/L 2 15 mg/L 5 mg/L.

2 mg/L.

[1] 5 mg/L.

03mg/L 3 15 mg/L 2 mg/L.

5 mg/L.

[1] 5 mg/L.

04 mg/L 4 15 mg/L 2 mg/L.

2 mg/L 3 mg/L.

06 mg/L 5 20 mg/L 2 mg/L.

2 mg/L.

[1] 5 mg/L.

04 mg/L 6 20 mg/L 2 mg/L.

5 mg/L 3 mg/L.

02 mg/L 7 20 mg/L 5 mg/L.

2 mg/L 3 mg/L.

03 mg/L 8 20 mg/L 5 mg/L.

5 mg/L.

[1] 5 mg/L.

03 mg/L TABLE IV. CALCULATION FOR CONTRIBUTION RATE OF FOUR COMPONENTS Component in medium First component amount Second component amount First average amount of PJ157 Second average amount of PJ157 Contribution rate Glucose concentration 15 mg/L 20 mg/L.

03 mg/L.

03 mg/L.

00175 mg/L Peptone concentration 5 mg/L 2 mg/L.

03 mg/L.

04 mg/L.

013 mg/L NaCl.

5 mg/L.

2 mg/L.

03mg/L.

04 mg/L.

13 mg/L Yeast extraction concentration 3 mg/L.

[1] 5 mg/L.

035 mg/L.

035 mg/L.

01745 mg/L.