A Novel Procedure for the Synthesis of 1,2:5,6-di-O-Isopropylidene-D-Glucofranose by Ultrasound

Abstract:

In the paper, synthesis of 1,2:5,6-di-O-isopropylidene-D-glucofranose (DAG) assisted by ultrasound were performed in the presence of ferric chloride as catalyst. The effects of some reaction parameters (e.g. power and frequency of ultrasound, reaction temperature, mass ratio of the reactant) on the yield were investigated. It was found that the reaction is greatly accelerated by the ultrasound in comparison to the control runs under mechanical stirring. The optimal ultrasound output power and frequency were found to be 200 W and 24 kHz at 40 °C with a 1:30 mass ratio of glucose to acetone. Under these optimal conditions, the yield of DAG reached 75.8%.

• Periodical: Advanced Materials Research (Volume 441)
• Pages: 408-412
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.441.408
• Online since: January 2012
• Authors: Yan Feng Tang, Xue Sheng Zhu, Jin Li Zhu, Jin Ming Wu, Hong Kun Zhao
• Keywords: 1,2:5,6-di-O-Isopropylidene-α-D-Glucofuranose, Glucose Derivative, Synthesis, Ultrasound (US)

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