Novel Organic-Inorganic Hybrid Nanoparticles as Non-Viral Gene Vector

Abstract:

Article Preview

Novel hybrid biomaterial of gelatin-siloxane nanoparticles (GS NPs), with positive surface potential and lower cytotoxicity, was synthesized through a 2-step sol-gel process. The pDNA-GS NPs complex was formulated with high encapsulation efficiency, and exhibited and efficient transfection in vitro. We thus envision that the GS NPs material could serve as non-viral gene vectors for gene therapy.

Info:

Periodical:

Advanced Materials Research (Volumes 47-50)

Edited by:

Alan K.T. Lau, J. Lu, Vijay K. Varadan, F.K. Chang, J.P. Tu and P.M. Lam

Pages:

1319-1322

DOI:

10.4028/www.scientific.net/AMR.47-50.1319

Citation:

Y. Zhao et al., "Novel Organic-Inorganic Hybrid Nanoparticles as Non-Viral Gene Vector", Advanced Materials Research, Vols. 47-50, pp. 1319-1322, 2008

Online since:

June 2008

Export:

Price:

$35.00

In order to see related information, you need to Login.