Novel Organic-Inorganic Hybrid Nanoparticles as Non-Viral Gene Vector

Yang Zhao; Pei Yin; Zu Yong Wang; Lei Ren; Qi Qing Zhang

doi:10.4028/www.scientific.net/AMR.47-50.1319

Paper Titles

Surface Morphological Changes Accompanying Dissolution of Bioactive Glass: Effect of Residual Stress
p.1302

Effect of pH Value on Synthesis of Calcium Phosphates
p.1307

Surfaces Modified by Amphiphilic Copolymer: Preparation and Application
p.1311

Near-IR Sensitive Au-Au₂S Nanoparticles with Biocompatibility for Drug Delivery
p.1315

Novel Organic-Inorganic Hybrid Nanoparticles as Non-Viral Gene Vector
p.1319

Bioassay Based on Photonic Crystal
p.1323

Distinctive Degradation Behaviors of Electrospun PGA, PLGA and P(LLA-CL) Nanofibers Cultured with/without Cell Culture
p.1327

A Retrievable Polymer Urethral Stent for Treatment of Urethral Strictures
p.1331

Activation of MAPK and NF-κB Induced by Biomaterials in Vascular Endothelial Cells
p.1335

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Novel Organic-Inorganic Hybrid Nanoparticles as Non-Viral Gene Vector

Abstract:

Novel hybrid biomaterial of gelatin-siloxane nanoparticles (GS NPs), with positive surface potential and lower cytotoxicity, was synthesized through a 2-step sol-gel process. The pDNA-GS NPs complex was formulated with high encapsulation efficiency, and exhibited and efficient transfection in vitro. We thus envision that the GS NPs material could serve as non-viral gene vectors for gene therapy.