Novel Organic-Inorganic Hybrid Nanoparticles as Non-Viral Gene Vector
Novel hybrid biomaterial of gelatin-siloxane nanoparticles (GS NPs), with positive surface potential and lower cytotoxicity, was synthesized through a 2-step sol-gel process. The pDNA-GS NPs complex was formulated with high encapsulation efficiency, and exhibited and efficient transfection in vitro. We thus envision that the GS NPs material could serve as non-viral gene vectors for gene therapy.
Alan K.T. Lau, J. Lu, Vijay K. Varadan, F.K. Chang, J.P. Tu and P.M. Lam
Y. Zhao et al., "Novel Organic-Inorganic Hybrid Nanoparticles as Non-Viral Gene Vector", Advanced Materials Research, Vols. 47-50, pp. 1319-1322, 2008