Near-IR Sensitive Au-Au2S Nanoparticles with Biocompatibility for Drug Delivery
The near-infrared (NIR) sensitive Au-Au2S nanoparticles (NPs) have shown many advantages as potential drug delivery systems. To further investigate biological safety of Au-Au2S NPs, cytotoxicity was estimated by calcein AM/EthD-1 fluorescence staining and the lactate dehydrogenase (LDH) release. The effects of NPs on apoptosis of CHL cells were determined by flow cytometry with Annexin V-FITC/PI double staining. It is evident that the Au-Au2S NPs are non-cytotoxic below IC50 dosage.
Alan K.T. Lau, J. Lu, Vijay K. Varadan, F.K. Chang, J.P. Tu and P.M. Lam
W. Liu et al., "Near-IR Sensitive Au-Au2S Nanoparticles with Biocompatibility for Drug Delivery", Advanced Materials Research, Vols. 47-50, pp. 1315-1318, 2008