Spectroscopic and Molecular Modeling Studies on Binding of Sparfloxacin to Humain Serum Albumin

Cheng Yu Dong; Ying Liu

doi:10.4028/www.scientific.net/AMR.518-523.494

Paper Titles

Research of Carbon and Nitrogen Ratio and Sludge Stability in Aerobic Granular Sludge Bioreactor
p.473

Research on COD Removal and SOUR of Aerobic Granule with Intermittent Aeration in Continuous Flow System
p.478

Response of Greenhouse Gas Emissions to Nitrogen Deposition in Terrestrial Ecosystem
p.485

Specific Death Symptoms and Organic Lesions of Blood Clam Tegillarca granosa in Acute Copper, Zinc, Lead and Cadmium Exposures
p.490

Spectroscopic and Molecular Modeling Studies on Binding of Sparfloxacin to Humain Serum Albumin
p.494

Stimulatory Effects of Extracts Prepared from Salix babylonica L. on Fat Catabolism in Mice Fed High-Fat Diet
p.498

Studies on the Community Structure of Phytoplankton in the Sea near Sanmen Bay
p.502

Study on Antimicrobial Activity and Chemical Components of Essential Oil from Michelia figo Spreng Leaves
p.509

Study on Evaluation Methods for Biodegradability and Biotoxicity of Industrial Effluents
p.516

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Spectroscopic and Molecular Modeling Studies on Binding of Sparfloxacin to Humain Serum Albumin

Abstract:

The interaction between sparfloxacin (SPFX) and human serum albumin (HSA) had been studied by spectroscopic and molecular modeling methods. The inner filter effect was eliminated to get accurate binding parameters. The site marker competition experiments revealed that SPFX binds to site I (subdomain IIA) of HSA and molecular docking was employed to further define the specific binding sites.