Study of In Vitro Reaction between Bone Cell and Poly(vinyl alcohol)-Matrix Composite Biomaterials
Aim of the study is to investigate the in vitro reaction between rat bone cell and poly (vinyl alcohol) (PVA)-matrix composites. Sample of Hydroxyapatite (HA) /PVA gel composites were prepared by the in situ growth method and Experiments of Alamar Blue Activity and Alkaline Phosphatase Assay were carefully made in our lab. SEM results displays that PVA-matrix composites containing HA fillers and pure PVA as a control group have an excellent biocompatible bone reaction in vitro with rat bone cells and HA filler particles in composites promote reaction between bone cell and composites. In vitro biology experiment resulted proves that adhesion, growth and differentiation of bone cells on all PVA-matrix composites are promoted by HA filler particles.
Helen Zhang and David Jin
C. Deng et al., "Study of In Vitro Reaction between Bone Cell and Poly(vinyl alcohol)-Matrix Composite Biomaterials", Advanced Materials Research, Vol. 531, pp. 296-299, 2012