An Efficient Synthesis of 3,4-Dihydorpymidine(1H)-(thio)-Ones Catalyzed by Novel SO₃H-Functionalized Ionic Liquids under Ultrasound Irradiation and Solvent Free Conditions

Abstract:

Novel SO3H-functionalized ionic liquids were successfully applied as catalysts for the one-pot three component Biginelli condensation under ultrasound irradiation without solvent. Various types of 3,4-dihydorpymidine(1H)-(thio)-ones were provided in 84-98% yields and conveniently separated from the reaction mixture by filtration, the dissolved catalyst could be reused with simple treatment. This novel synthetic method is especially favoured because it provides a synergy between ionic liquids and ultrasound irradiation which offers the advantages of high yields, short reaction times, simplicity, and easy workup compared to the conventional methods reported in the literature

• Periodical: Advanced Materials Research (Volume 531)
• Pages: 428-431
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.531.428
• Online since: June 2012
• Authors: Bai Lin Li, Chang Hua Ge, An Guo Ying
• Keywords: Biginelli Reaction, Dihydropyrimidinone, Ionic Liquid (IL), Ultrasound irradiation

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