Study on Biocompatibility of Post-Irradiated Silk Fibroin In Vitro

Huan Yu Jin; Yu Liu; Xing Liu; Da Peng Wang; Jian Liu; Hua Yin; Yan An

doi:10.4028/www.scientific.net/AMR.535-537.2357

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Study on Biocompatibility of Post-Irradiated Silk Fibroin In Vitro
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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 535-537Study on Biocompatibility of Post-Irradiated Silk...

Study on Biocompatibility of Post-Irradiated Silk Fibroin In Vitro

Abstract:

Because of the good biocompatibility, silk fibroin is widely applied in the biomedical area. However, a few of sensitive persons still have the allergic effect after receiving the recovery treatments involving the silk fibroin used. In present research, we had the SD rat dermal cells cultured on the silk fibroin film (irradiated by gamma ray with the doses of 25kGy and 50kGy) and tested the cell grown curve and proliferation activity of the cells in the silk fibroin extracts from the CCK-8 test kit. The result showed that the cells cultured on the 50kGy-irradiated film grown more quickly than that on the 25kGy-irradiated film and the control. Moreover, cells in the 50kGy-irradiated film extract had the most proliferation activity. In conclusion, the results indicated that the silk fibroin irradiated with higher gamma ray dose could stimulate the cells growth and proliferation.

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Periodical:

Advanced Materials Research (Volumes 535-537)

Pages:

2357-2360

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.535-537.2357

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Online since:

June 2012

Authors:

Huan Yu Jin, Yu Liu, Xing Liu, Da Peng Wang, Jian Liu, Hua Yin, Yan An

Keywords:

Biocompatibility, Gamma Ray, Growth Curve, Proliferation Activity, Silk Fibroin

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References

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