Research on the Correlation between Neuronal Damage and Drug Resistance Gene Product P-Gp Following Status Epilepsy

Song Yan Liu; Rui Tao Mao; Hua Cai; Xue Mei Han

doi:10.4028/www.scientific.net/AMR.550-553.1010

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Research on the Correlation between Neuronal Damage and Drug Resistance Gene Product P-Gp Following Status Epilepsy
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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 550-553Research on the Correlation between Neuronal...

Research on the Correlation between Neuronal Damage and Drug Resistance Gene Product P-Gp Following Status Epilepsy

Abstract:

Objective: To study the association between neuronal injury following status epilepsy and expression of P-glycoprotein, discuss the association between intractable epilepsy and neuronal injury. Method: To establish a mice status epilepticus model by lithium-pilocarpine injected intraperitoneal, The mice were randomly divided into control group 6h, 12h, 1d, 3d, 5d and 7d after status epilepticus(SE) .To research the neuronal injury by image analysis method, expression of P-gp in blood was studied by flow cyometry .To analyze the association between neuronal injury and expression of P-gp by Pearson statistics. Result: The neuronal injury was observed after status epilepsy. Neuronal injury is most obvious 3-7 days after status epilepsy, expression of P-gp increased simultaneously. The severity of neuronal injury has a positive correlation to expression of P-gp. Conclusion: Association between intractable epilepsy and neuronal injury exists.

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Periodical:

Advanced Materials Research (Volumes 550-553)

Pages:

1010-1013

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.550-553.1010

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Online since:

July 2012

Authors:

Song Yan Liu, Rui Tao Mao, Hua Cai, Xue Mei Han

Keywords:

Intractable Epilepsy, Neuronal Damage, P-Glycoprotein, Status Epilepsy

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