Toxicity Mechanism of Formic Acid is Directly Linked to ROS Burst and Oxidative Damage in Yeast Saccharomyces cerevisiae

Abstract:

In this paper the survival rate of Saccharomyces cerevisiae cells after the formic acid treatment of different concentration was determined firstly, and cells of Saccharomyces cerevisiae were labeled with fluorescent probes of reactive oxygen species (ROS) and treated with formic acid, then intracellular reactive oxygen species was detected with confocal microscopy and flow cytometer. The results show that formic acid can lead to the rapid burst of intracellular reactive oxygen species. We speculated that the outbreak of the formic acid-induced reactive oxygen species and corresponding oxidative damage is the leading cause of the yeast cells death.

• Periodical: Advanced Materials Research (Volumes 550-553)
• Pages: 1060-1065
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.550-553.1060
• Online since: July 2012
• Authors: Lin Du
• Keywords: Formic Acid, Oxidative Damage, ROS Burst, Saccharomyces cerevisiae

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