Preliminary Research on the Interaction between a Novel Designed Self-Assembling Peptide with Half-Sequence Ionic Complement and the Natural Product Psoralen

Abstract:

This paper describes a new kind of 9-residue half-sequence ionic-complementary peptide P-X7-P, which can spontaneously self-assemble into well-ordered and long interconnected nanofibrilar network structure in pure water, and can be used as a hydrophobic compounds carrier. Psoralen, a natural product, is slight water soluble but has various treatments in medicine. In order to fully understand the interaction between the self-assembling peptide and psoralen,the nanostructures formed by two of them were characterized by atomic force microscopy (AFM), field-emission scanning electron microscopy (FE-SEM). This work provides insights on the interaction between the amphiphilic self-assembling peptide and psoralen that are useful for the bottom up development of peptide sequence for local natural product drug delivery applications.

• Periodical: Advanced Materials Research (Volumes 550-553)
• Pages: 1580-1585
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.550-553.1580
• Online since: July 2012
• Authors: Li Li Tang, Fu Yi Guan, Dao Hang He
• Keywords: Interaction, Nanostructure, Psoralen, Self-Assembling Peptide

References

[1] M.C. Branco, J.P. Schneider：submitted to Biomaterials (2010)

[2] S.Zarzhitsky, H.Rapaport: submitted to Journal of Colloid and Interface Science (2011)

[3] M.E. Davis, J.P.M. Motion, D.A. Narmoneva, T.Takahashi, D.Hakuno, R.D. Kamm and S.G. Zhang: submitted to Circulation (2005)

[4] J.K. Kretsinger, L.A. Haines, B.Ozbas, D.J. Pochan and J.P. Schneider: submitted to Biomaterials (2005)

[5] S.G. Zhang, T.Holmes, C.Lockshin and A.Rich: submitted to Proceedings of the National Academy of Sciences of the United States of America (1993)

[6] X.J. Zhao: submitted to Current Opinion in Colloid & Interface Science (2009)

[7] X.J. Zhao, S.G. Zhang: submitted to Bioscience (2007)

[8] X.J. Zhao, S.G. Zhang: submitted to Chemical Society Reviews (2006)

[9] S.Vauthey, S .Santoso and S. G. Zhang: submitted to Proceedings of the National Academy of Sciences of the United States of America(2002)

[10] S.G. Zhang, F.Gelain and X.J. Zhao: submitted to Seminars in Cancer Biology (2005)

[11] R.G. Ellis-Behnke, Y.X. Liang, D.K.C. Tay, P.W.F. Kau, G.E. Schneider and S.G. Zhang: submitted to Proceedings of the National Academy of Sciences of the United States of America (2006)

[12] S.G. Zhang: submitted to Biotechnology Advances (2002)

[13] S.S. Santoso, S.Vauthey and S.G. Zhang: submitted to Current Opinion in Colloid & Interface Science (2002)

[14] C.Keyes-Baig, J.Duhamel, S.Y. Fung, J.Bezaire and P.Chen: submitted to Journal of the American Chemical Society (2004)

[15] S.Y. Fung, H.Yang, P.T. Bhola and P.Chen: submitted to Advanced Functional Materials (2009)

[16] L.P. Ruan, H.Y. Zhang, H.L. Luo and X.J. Zhao: submitted to Proceedings of the National Academy of Sciences of the United States of America (2009)

[17] H.Song, L.L. Zhang and X.J. Zhao: submitted to Macromolecular Bioscience (2010)

[18] Z.Y.Ye, H.Y. Zhang, H.L. Luo, S.K. Wang and X.J. Zhao: submitted to Journal of Peptide Science (2008)

[19] R.Sneer, M.J. Weygand and D.A. Tirrell: submitted to Chemical Physics and Physical Chemistry (2004)

[20] R.M. Liu, A.F.Li and A.L. Sun: submitted to Journal of Chromatography A (2004)

[21] C.V. Hanson: submitted to Blood Cells (1992)

[22] D.Z. Tang, F.Yang and Z.Yang: submitted to Biochemical and Biophysical Research Communications (2011)

[23] H.S. Jois, B.L. Manjunath: submitted to Journal of the Indian Chemical Society (1933)

[24] E.J. Gunther, T.M. Yeasky and F.P. Gasparro: submitted to Cancer Research (1996)

[25] S.M. Clark, S.M. Wilkinson: submitted to Contact Dermatitis ( 1998)