Chemical Constituents and Anti-Tumor Activity of Gentiana farreri

Abstract:

Five triterpenoids were isolated from Gentiana farreri, which was used as traditonal Tibetan medicine in the treatment of some diseases. Their structures were identified as: pseudotaraxasterol (1), lupeol (2), ursolic acid (3), 2α, 3ß-dihydroxylursolic acid (4), 2α,3ß-dihydroxyloleanolic acid (5). All these compounds were isolated from G. farreri for the first time. The cytotoxic activity on the growth of HepG-2 cells of all compounds were investigated in MTT assay, the results showed that compound 3, 4, 5 have high cytotoxic activity, IC50 is 100.88, 13.03, 13.19 (μg/ml), respectively.

• Periodical: Advanced Materials Research (Volumes 554-556)
• Pages: 1682-1685
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.554-556.1682
• Online since: July 2012
• Authors: Ai Mei Yang, Jing Sun, Hui Li, Hui Jun Yuan, Jie Li Liu
• Keywords: Anti-Tumor Activity, Gentiana farreri, Riterpenoid

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