Electrochemical Behavior of Promethazine Hydrochloride and its Interaction with Bovine Serum Albumin

Abstract:

In this paper, the electrochemical behavior of promethazine hydrochloride (PMT) and its interaction with bovine serum albumin (BSA) were studied by means of cyclic voltammetry. In pH 6.5 Tris-HCl buffer solution, PMT exhibits a pair of reversible peaks and an irreversible oxidation peak at a bare gold electrode. The electrode reactions are the process controlled by adsorption. The results of cyclic voltammetry suggest that a BSA-PMT complex is formed, and this complex is not electroactive. The absorption spectra confirm the binding PMT to BSA. The binding number m and the binding constant β of BSA binding to PMT are 2.10 and 7.43×10⁵ L/mol, respectively.

• Periodical: Advanced Materials Research (Volumes 554-556)
• Pages: 450-453
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.554-556.450
• Online since: July 2012
• Authors: Ling Ling He, Xin Wang, Bin Liu, Rui Mei Xu
• Keywords: Bovine Serum Albumin (BSA), Cyclic Voltammetry (CV), Electrochemical Behavior, Interaction, Promethazine Hydrochloride

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