Design and Simulation of Ascending Curvilinear Micro Channel for Cancer Cell Separation from Blood

Abstract:

Cancer is one of the leading causes for human death. However, if cancer cells are identified at initial stage, patient treatment will be low cost and successful. This research presents the design and simulation of ascending curvilinear micro channel for separation of particles resembling cancer cells. The separation system is designed and simulated by using inertia focusing cell separation technique. Computational fluid dynamics (CFD) design and simulation of ascending micro channel for cell separation using inertial focusing technique is used for separation. The simulation was carried in two stages; for focusing and separation. The mixture flow velocities were 0.105 m/s, 115 m/s and 125 m/s, and with Reynolds number Re = 8.5, 9.25 and 10.06. The ascending curvilinear channel design demonstrated favorable focusing, and separation. 100% purity and 100 % efficiency for separation of 15 µm particles was achieved at Re = 8.50 and maximum output/input ratio at velocity 0.105m/s. Cancer cells are also of size about 15 µm and the our proposed micro channel is a good candidate for cancer cells separation from blood.

• Periodical: Advanced Materials Research (Volumes 557-559)
• Pages: 2361-2366
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.557-559.2361
• Online since: July 2012
• Authors: W.A.H.S.S Wewala, Nitin Afzulpurkar, Jafar Khan Kasi, Ajab Khan Kasi, Amporn Poyai, Dhananjay W. Bodhale
• Keywords: Ascending, Cancer Cell, Computational Fluid Dynamics (CFD), MEMS, Micro-Channel, Micro-Fluidics, Simulation

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