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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 591-593Preparation and In Vitro Degradation of PLGA/HA...

Preparation and In Vitro Degradation of PLGA/HA Composite Fiber Scaffolds by Electrospinning

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Abstract:

The preparation of scaffolds consisted of a polymer composites with inorganic materials has received extensive attention in the field of tissue engineering recently.Electrospinning is a good method to obtain nano-scaled fibers from polymer solutions. In this paper ,we successfully prepared nanofibers of poly(lactide-co-glycolde) (PLGA)/hydroxyapatite(HA)by electrospinning.Their structure morphology and degradation behaviors were studied.The in vitro degradation of PLGA/ HA composite membranes was examined for up to 16 weeks in phosphate-buffered saline (PBS, pH 7.4) at 37°C. The results indicated that the surface of hybrid fibers was much coarser because of the introduction of HA nano-particles. The alkaline HA nano-particles inhibited the self-catalysis of PLGA during the degradation and slowed down the degradation rates of hybrid fibers.The introduction of hydroxyapatite component changed the hydrophilic/hydrophobic balance and, thus, influenced degradation behavior and mechanical properties of the composite membranes during degradation. The preliminary results show that comprehensive properties are well better on the hybrid scaffolds than pure scaffolds and PLGA/ HA bionanocomposites have the potential in tissue regeneration applications.

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Periodical:

Advanced Materials Research (Volumes 591-593)

Pages:

982-988

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.591-593.982

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Online since:

November 2012

Authors:

Xu Fan Xu

Keywords:

Electro-Spinning, Hybrid Scaffold Biocompatibility, Hydroxyapatite (HAP), Nanofiber, Poly(lactide-co-glycolde)

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© 2012 Trans Tech Publications Ltd. All Rights Reserved

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[1] S. Liao, C.K. Chan and S. Ramakrishna: Frontiers of Materials Science in China, Vol. 4 (2010) No. 1, p.29.

[2] J.J. Norman and T.A. Desai: Annals of Biomedical Engineering, Vol.34, (2006) No.1, p.89.

[3] Y. Z. Zhang and C. T. Lim: JOM Journal of the Minerals, Metals and Materials Society, Vol.60 (2008) No. 6, p.45.

[4] Y.Z. Zhang, C.T. Lim, S.Ramakrishna and Z.M. Huang: Journal of Materials Science: Materials in Medicine, Vol.16,(2005)No.10, p.993.

[5] S. Srouji, T. Kizhner, E. Suss-Tobi, E. Livne and E. Zussman: Journal of Materials Science: Materials in Medicine, Vol. 19(2008)No.3, p.1249.

DOI: 10.1007/s10856-007-3218-z

[6] H.Q. Geng, H.Song, J.Qi and D.X. Cui: Nanoscale Research Letters, Vol. 6 (2011) No.1, p.312.

[7] N. T.Hiep and B-T. Lee: Journal of Materials Science: Materials in Medicine, Vol.21 (2010)No.6, p.1969.

[8] J. Venugopal, Sharon Low, Aw Tar Choon, T. S. Sampath Kumar and S. Ramakrishna: Journal of Materials Science: Materials in Medicine, Vol.19(2008) No.5, p.2039.

[9] P.C. Caracciolo, V.Thomas, Y.K. Vohra, F. Buffa and G. A. Abraham: Journal of Materials Science: Materials in Medicine, Vol. 20(2009)No.10, p.2129.

[10] A.Di Martino, L.Liverani, A.Rainer, G.Salvatore and M. Trombetta: Musculoskeletal Surgery, Vol.95( 2011) No.2, p.69.

DOI: 10.1007/s12306-011-0097-8

[11] B.Rentsch, A.Hofmann, A.Breier, C.Rentsch and D.Scharnweber: Annals of Biomedical Engineering, Vol.37 (2009) No.10, p.2118.

DOI: 10.1007/s10439-009-9731-0

[12] H.j.Wu, J.T. Fan, C-C.Chu and J.Wu: Journal of Materials Science: Materials in Medicine, Vol.21 (2010) Number 12, p.3207.

[13] J.Zhao, Y.P. Zhao, W.Zhang, X.Y. Yuan and K.D. Yao: Chinese Science Bulletin, Vol.54 (2009) No.8, p.1328.

[14] C.Ma, D.L. Huang, H.C. Chen, D.L. Chen and Z.C. Xiong: Journal of Polymer Research, Vol.19(2012 )No. 2, p.9803.

[15] I.S. Lee, O.H. Kwon, W. Meng, I-K.Kang and Y.Ito: Macromolecular Research, Vol.12 (2004) No. 4, p.374.

[16] G-J.Wang, Y-C.Lin, C-W.Li, C-C.Hsueh and S-H.Hsu:Biomedical Microdevices, Vol. 11(2009) No.4, p.843.

[17] C. M. Hwang, Y. Park, J. Y. Park, K. Lee and K. Sun: Biomedical Microdevices, Vol.11(2009)No. 4, p.379.

[18] S-J.Liu, K-M.Peng, C-Y.Hsiao, K-S.Liu and H-T.Chung: Annals of Biomedical Engineering, Vol.39 (2011) No.11, p.2759.

[19] R.A. Franco, T.H. Nguyen and B-T.Lee:Journal of Materials Science: Materials in Medicine, Vol.22 (2011) No.10, p.2207.

[20] A.Rainer, C.Spadaccio, P.Sedati, F.D. Marco and S.Carotti: Annals of Biomedical Engineering, Vol.39 (2011) No.7, p.1882.

[21] A. A. Salifu, B. D. Nury and C. Lekakou: Annals of Biomedical Engineering, Vol.39 (2011) No.10, p.2510.

[22] E. Kon, G.Filardo, M.Delcogliano, M.Fini and F.Salamanna: BMC Musculoskeletal Disorders, Vol.11 (2010) No.1, p.220.

[23] J.M. Qian, Y.H. Kang, W. Zhang and Z.Li: Journal of Materials Science: Materials in Medicine, Vol.19 (2008) No.11, p.3373.

[24] Y.O.Wu, L.L. Bench, J.Du and K.L. Choy Communicalions of the American Ceramic Society Vol.87(2004) No.10, p.1988.