Pore Size Gradient Hydroxyapatite Scaffolds with Interconnected Pores Fabricated by a Template Method

Abstract:

Pore size gradient hydroxyapatite scaffolds with interconnected pores were fabricated using a novel template with graded polymer beads and slip casting. The microstructure, phase, porosity, and compression strength of the fabricated pore size gradient HA scaffolds were characterized. The scaffolds were also examined for their cell compatibility in vitro using human osteosarcoma (HOS) cells. By using a polymer template with graded sizes, the scaffolds showed gradually increasing pore size of approximately 177-578 μm and interconnection size ranges from 71.5-290.7 μm along the cylindrical axis. The porosity of selected sections of the pore size gradient HA scaffolds ranged from 62.4-71.2%, while the compressive strength decreased from 8.1-3.72 MPa as the pore size and NaCl content increased. HOS cells showed best growth in sections of the scaffold with pore sizes of 480-578 μm.

• Periodical: Advanced Materials Research (Volumes 602-604)
• Pages: 1219-1222
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.602-604.1219
• Online since: December 2012
• Authors: Yu Fei Tang, Kang Zhao, Long Hu
• Keywords: Cell Compatibility, Hydroxyapatite (HAP), Interconnected Pore, Pore Size Gradient, Slip Casting

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