Inhibitory Activity of Extracts from Mycelia Materials of Several Mushrooms on the Angiotensin I-Converting Enzyme

Abstract:

ACE inhibitory activities of water extracts from mycelia of 6 kinds of mushrooms in liquid fermentation were investigated. All strains cultivated in shaking flask containing liquid medium, and yield of mycelia ranged from 0.051 to 1.392 g mycelia/day/L liquid medium in average. Resulting mycelia were extracted with distilled water at 50°Cfor 200 min, and the yield of water extracts from mycelia ranged from 287.475 to 490.088 mg/g dried mycelia. These water extracts were used to assay their ACE inhibitory activity. Results showed that their IC50 values ranged from 1.277 to 5.250 mg/ml. The difference among IC50 values of these water extracts were significant (p<0.05 or p<0.001). Lactarius camphorates (IC50: 1.646±0.061mg/mL) was the specie which had relatively lower IC50 value than others, as well as relatively higher water extract yield. The results highlighted the potential for making antihypertensive functional foods or drugs from liquid cultured mycelia of Lactarius camphorates.

• Periodical: Advanced Materials Research (Volumes 610-613)
• Pages: 3541-3544
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.610-613.3541
• Online since: December 2012
• Authors: Pei Sheng Yan, Xiu Jun Gao
• Keywords: ACE Inhibitor, Anti-Hypertension, Edible/Medicinal Mushrooms, Liquid Fermentation

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