The Effect of Amount of Surfactant and Types of Drug on Amorphous Silica Drug Delivery System (DDS)

Abstract:

This study describes the formation of silica nanocolloids for drug delivery system (DDS) via micelles formation approach. Micelles formed above critical micelle concentration (CMC) of the surfactant in aqueous solution. In this study, non-ionic Tween 80 was used as a surfactant and its effect on size and distribution of silica nanocolloids DDS was systematically studied. From transmission electron microscope (TEM) images, the size of silica increased from 30 nm to 50 nm with increasing amount of Tween 80 from 0.02 wt%, 0.0275wt%, 0.035wt% and 0.045 wt% respectively. Silica DDS with 0.0275wt% as optimum amount of Tween 80 encapsulated poor water soluble drug, Rifampicin has larger size (~53.8 nm) with better encapsulation efficiency compared to silica DDS encapsulated water soluble drug, Isoniazid (~39.9 nm). X-ray diffraction spectrum shows that silica DDS produced is in amorphous structure. Stability test of silica DDS encapsulated Rifampicin in 1M Sodium Chloride (NaCl) and 1% mouse serum are 42.78 % and 64.91%, respectively, which is inacceptable range for drug delivery application.

• Periodical: Advanced Materials Research (Volume 620)
• Pages: 112-116
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.620.112
• Online since: December 2012
• Authors: Azwana Ab Wab Hajarul, Abdul Razak Khairunisak, Dyana Zakaria Nor, Abdul Aziz Azlan
• Keywords: Amorphous Silica, Drug Delivery System, Isoniazid, Micelles, Rifampicin

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