New α-Glucosidase Inhibitory Polysaccharides Isolated from Marine Green Algae Enteromorpha Linza

Abstract:

The crude polysaccharides were extracted by hot water from marine green algae Enteromorpha linza. After that, five polysaccharides were obtained through Q-Sepharose Fast Flow chromatography. Their structures and monosaccharide compositions were analyzed by FTIR and GC-MS. Mannose was the abundant monosaccharide in both ELP-3 and ELP-4. ELP-3 consisted of mannose, L(-)-fucose, D-glucose, D-galactose, D-arabinose and D-xylose in a molar ratio of 1.00:0.66:0.46:0.41:0.27:0.19. In α-glucosidase inhibition assay, the polysaccharides showed significant inhibitory activities. ELP-3 (IC₅₀ =0.36 mg/mL) exhibited much stronger inhibitory effect against α-glucosidase, compared with Acarbose (IC₅₀=0.46 mg/mL), while ELP-4, a similar inhibitory effect (IC₅₀=0.58 mg/mL) as Acarbose. Moreover, it was found that EPLs have moderate antioxidant activities in 1,1-diphenyl-2-picrylhydrazil (DPPH) scavenging experiment.

• Periodical: Advanced Materials Research (Volumes 634-638)
• Pages: 1010-1015
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.634-638.1010
• Online since: January 2013
• Authors: Li Xin Zhang, Ning Zhang, Jinhua Li, Zhonghua Wang
• Keywords: Antioxidant Activity, Enteromorpha linza, Polysaccharide, α-Glucosidase

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