Study on Synthesis of N-Methyldipeptide N-Ns-N(Me)-L-Ala-N(Me)-L-lle-OtBu

Xiao Ji Wang; Jian Ting Zhang; Dong Wang Liu; Lin Jun Tang; Yang Li

doi:10.4028/www.scientific.net/AMR.634-638.1108

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 634-638Study on Synthesis of N-Methyldipeptide...

Study on Synthesis of N-Methyldipeptide N-Ns-N(Me)-L-Ala-N(Me)-L-lle-O^tBu

Abstract:

The hindered N-methyldipeptide (N-Ns-N(Me)-L-Ala-N(Me)-L-Ile-OtBu), a segment of the new cyclodepsipeptide Apratoxin A^[1] , which exhibit cytotoxycity against human tumor cell lines, was synthesized from L-Alanine and L-iso-Leucine through ten steps in overall yield of 49.4%.

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Periodical:

Advanced Materials Research (Volumes 634-638)

Pages:

1108-1111

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.634-638.1108

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Online since:

January 2013

Authors:

Xiao Ji Wang, Jian Ting Zhang, Dong Wang Liu, Lin Jun Tang, Yang Li

Keywords:

L-Alanine, L-Iso-Leucine, N-Methyldipeptide

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References

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