Study on Synthesis of 2,2-Dimethyl-3-Hydroxy-7-Octynoic Acid

Xiao Ji Wang; Jian Ting Zhang; Dong Wang Liu; Lin Jun Tang; Jun Min Feng; Shi Peng Chen

doi:10.4028/www.scientific.net/AMR.634-638.1103

Paper Titles

Study on the Thermodynamic Properties of Two Anti-Cancer Drugs
p.1086

Study on Preparation of Abamectin Microcapsule with Interfacial Polymerization
p.1090

Study on Synthesis of (s)-3-(t-Butyldimethylsilyloxy)-7,7-Dichloro-2,2-Dimethyloctanoic Acid
p.1095

Study on Synthesis of 2-(1-Tert-Butoxycarbonylamino-2-Methyl-Butyl)-Thiazole-4-Carboxylic Acid Methyl Ester
p.1099

Study on Synthesis of 2,2-Dimethyl-3-Hydroxy-7-Octynoic Acid
p.1103

Study on Synthesis of N-Methyldipeptide N-Ns-N(Me)-L-Ala-N(Me)-L-lle-O^tBu
p.1108

Synthesis and Anti-HIV Integrase Inhibitory Activity of β-Diketo Derivatives of Mono-Substituted Calix[4]arene
p.1112

Synthesis and Biological Evaluation of Quinolone Acid Derivatives Having Polyhydroxylated Aromatics as HIV-1 Integrase Inhibitions
p.1116

The Application of Silk Fibroin in Tissue Engineering and Drug Carrier Area
p.1120

HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 634-638Study on Synthesis of...

Study on Synthesis of 2,2-Dimethyl-3-Hydroxy-7-Octynoic Acid

Abstract:

Pitipeptolide A can be disconnected across the amide bind to afford t-Boc-glycine, the linear depsipeptide and the Dhoya fragment. 2,2-dimethyl-3-hydroxy-7-octynoic acid unit was prepared in eight steps from 1,5-pentanediol monobenzyl ether. including oxidation, TBS protection, deprotection and Saponification with (1M) sodium hydroxide solution gave the Dhoya unit (8) in 75% overall yield.