Synthesis and Anti-HIV Integrase Inhibitory Activity of β-Diketo Derivatives of Mono-Substituted Calix[4]arene

Zai Gang Luo; Xue Mei Xu; Ming Yang Zhang; Kuai He; Xiao Mei Zhang

doi:10.4028/www.scientific.net/AMR.634-638.1112

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 634-638Synthesis and Anti-HIV Integrase Inhibitory...

Synthesis and Anti-HIV Integrase Inhibitory Activity of β-Diketo Derivatives of Mono-Substituted Calix[4]arene

Abstract:

Six β-diketo derivatives of mono-substituted calix[4]arene were synthesized as potential HIV-1 integrase inhibitors and evaluated their inhibition to the strand transfer process of HIV-1 integrase. Their structures were characterized by NMR and HRMS. All the title compounds as potential HIV-1 integrase inhibitors proved to be active in the micromolar range (6.7–37.6 μM) on the strand transfer step.

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Periodical:

Advanced Materials Research (Volumes 634-638)

Pages:

1112-1115

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.634-638.1112

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Online since:

January 2013

Authors:

Zai Gang Luo, Xue Mei Xu, Ming Yang Zhang, Kuai He, Xiao Mei Zhang

Keywords:

Calix[4]Arene, HIV-1, Integrase Inhibitors, Strand Transfer, β-Diketo Derivatives

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