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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 634-638A Genetic Threading Method with Combined...

A Genetic Threading Method with Combined Structure- and Sequence-Based Information

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Abstract:

A threading program based on genetic algorithm, is proposed for the protein fold recognition problem. Proper algorithm is designed in which genetic operators can be effectively implemented, and a more realistic energy model is adopted in this work. The performance of the genetic threading method is tested on a standard fold recognition benchmark, and the results show that the genetic threading method has good alignment accuracy and fold recognition ability. The analysis of the results demonstrates the rationality of our energy model.

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Periodical:

Advanced Materials Research (Volumes 634-638)

Pages:

3930-3935

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.634-638.3930

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Online since:

January 2013

Authors:

Jun Feng Gu, Xi Cheng Wang

Keywords:

Genetic Algorithm (GA), NP-Complete, Protein, Threading

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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