Preparation of 2-Methyl-1,4-Naphthoquinone(vitamin K₃) by Catalytic Oxidation of 2-Methylnaphthalene with Sulfuric Acid as Catalyst

Abstract:

The oxidation of 2-methylnaphthalene(2-MN) to 2-methyl-1,4-naphthoquinone(2-MNQ, Vitamin K3) was accomplished in acetic acid with the application of hydrogen peroxide as oxidant. The yield of 2-MNQ was up to 81.3% when sulfuric acid used as catalyst. The catalyst exhibits excellent substrate conversion and target product selectivity. Different parameters affecting the oxidation of 2-methylnaphthalene with hydrogen peroxide catalyzed by sulfuric acid were described, such as reaction temperature, reaction time, dosage of hydrogen peroxide, and amount of sulfuric acid. Compared with the traditional methods for the preparation of Vitamin K3 with yield of only 30-50%, this method presented could be more effective, economical and ecofriendly.

• Periodical: Advanced Materials Research (Volumes 634-638)
• Pages: 664-668
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.634-638.664
• Online since: January 2013
• Authors: Ming Hao Zhou, Ting Feng Yan, Hong Yan Zhu, Guo Min Xiao
• Keywords: 2-Methyl-1,4-Naphthoquinone, 2-Methylnaphthalene, Hydrogen Peroxide, Oxidation, Sulfuric Acid, Vitamin K₃

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