Bioinformatics Analysis of the Complete Nucleotide Sequence of UL17 Gene from Duck Enteritis Virus

Abstract:

Duck enteritis virus (DEV) is a herpesvirus that causes an acute, contagious, and fatal disease. Our laboratory had identified and sequenced the DEV-UL17 gene, one of the conservative genes of this viral genome. It is a 2055bp segment, GenBank accession NO. 643567. Here in this article we used kinds of bioinformatics softwares and online web servers to analyze the nucleotide sequence of this gene for further research. The phylogenetic tree of the DEV-UL17 protein and its homologs of other 19 reference herpesviruses revealed that DEV had close evolutionary relationship with Meleagrid herpesvirus1, Gallid herpesvirus 2 and Gallid herpesvirus 3, the members of genus Mardivirus. In addition, multiple epitopes and potential motifs were found in DEV-UL17 protein and they may play an important role in in the function of immune system, it may greatly influence the antibodies and genetic vaccine, or in the clinical diagnosis of DEV.

• Periodical: Advanced Materials Research (Volume 647)
• Pages: 227-231
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.647.227
• Online since: January 2013
• Authors: Ting Wen, An Chun Cheng, Ming Shu Wang
• Keywords: Bioinformatic Analysis, DEV, Nucleotide Sequence, UL17 Gene

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