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Alginate–Chitosan Nanocapsules for Controlled Release of Low Molecular Drugs Tegafur and DHAD

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Abstract:

Alginate–chitosan nanocapsules (Alg-CS NCs) were prepared by a two-stage process. The NCs were loaded with two low molecular drugs-tegafur and Mitoxantrone Hydrochloride(DHAD). Results revealed that these two drugs exhibited different drug loading and release characteristics. The drug loading and encapsulation efficiency of tegafur (<1%) were both lower than those of DHAD with the drug loading at about 20%~60% and encapsulation efficiency over 90%. However, tegafur showed a visible burst release phenomenon and the cumulative release rate of tegafur was much higher than that of DHAD.

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Periodical:

Advanced Materials Research (Volume 647)

Pages:

264-268

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.647.264

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Online since:

January 2013

Authors:

Yuan Gang Liu, Hong Hao Mao, Shi Bin Wang, Qing Qing Sun

Keywords:

Alginate, Chitosan, DHAD, Nanocapsules, Tegafur

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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References

[1] L.F. Weikersthal, A. Schalhorn, M. Stauch, et al: European Journal of Cancer Vol. 47 (2011), p.206.

Google Scholar

[2] A. Torre, J. Romero, A. Montero, et al: Tumori Vol. 94 (2008), p.453.

Google Scholar

[3] K. Katsumata, H. Tomioka, M. Kusama, et al: Cancer Chemother Pharmacol Vol. 52 (2003), p.86.

Google Scholar

[4] A. Cricca, A. Marino, D. Valenti, et al: Anticancer Research Vol. 26 (2006), p.2301.

Google Scholar

[5] M. Herold, A. Haas, S. Srock, et al: Journal of Clinical Oncology Vol. 25 (2007), p. (1986).

Google Scholar

[6] A.V. Novoselac, S. Reddy and J. Sanmugarajah: Leukemia Vol. 18 (2004), p.1561.

Google Scholar

[7] A. Beyerle, S. Höbel and F. Czubayko: Toxicology in Vitro Vol. 23 (2009), p.500.

Google Scholar

[8] S.Y. Yen, K.C. Sung, J. J Wang, et al: International Journal of Pharmaceutics Vol. 220 (2001), p.91.

Google Scholar

[9] R.C. Mundargi, N.B. Shelke, A.P. Rokhade, et al: Carbohydrate Polymers Vol. 71 (2008), p.42.

Google Scholar

[10] Y. Sun, J.C. Wang, X. Zhang, et al: Journal of Controlled Release Vol. 129 (2008), p.192.

Google Scholar

[11] D.D. Stefano, G.D. Rosa, M.C. Maiuri, et al: Pharmacological Research Vol. 60 (2009), p.33.

Google Scholar

[12] P. Ines, A. Niuris and H. Angeles: Current Drug Discovery Technologies Vol. 5 (2008), p.333.

Google Scholar

[13] A.H. Ghassemi, M.J. Steenbergen, H. Talsma, et al: Journal of Controlled Release Vol. 138 (2009), p.57.

Google Scholar

[14] Rinaudo M: Progress In Polymer Science Vol. 31 (2006), p.603.

Google Scholar

[15] M. Goldberg, R. Langer and X.Q. Jia: Journal of Biomaterials Science-Polymer Edition Vol. 18 (2007), p.241.

Google Scholar

[16] E. Taqieddin and M. Amiji: Biomaterials Vol. 25 (2004), p. (1937).

Google Scholar

[17] J. Xi, L. Zhou and Y. Fei: International Journal of Biological Macromolecules Vol. 50 (2012), p.157.

Google Scholar

[18] A. Pei, Z. Shen and G. Yang: Materials Letters Vol. 61 (2007), p.2757.

Google Scholar

[19] M. Sokolsky-Papkov, K. Agashi, A. Olaye, et al: Advanced Drug Delivery Reviews Vol. 59 (2007), p.187.

DOI: 10.1016/j.addr.2007.04.001

Google Scholar

[20] N.M. Alves and J.F. Mano: International Journal of Biological Macromolecules Vol. 43 (2008), p.401.

Google Scholar

[21] Y. Xu and Y. Du: International Journal of Pharmaceutics Vol. 250 (2003), p.215.

Google Scholar

[22] S. Özbaş-Turan, J. Akbuğa and C. Aral: Journal of Pharmaceutical Sciences Vol. 91 (2002), p.1245.

Google Scholar

[23] Y.C. Huang, M.K. Yeh and C.H. Chiang: International Journal of Pharmaceutics Vol. 242 (2002), p.239.

Google Scholar

[24] S.A. Agnihotri and T.M. Aminabhavi: Journal of Controlled Release Vol. 96 (2004), p.245.

Google Scholar

[25] P. Zhang, G. Ling, X. Pan, et al: Nanomedicine: Nanotechnology, Biology, and Medicine Vol. 8 (2012), p.185.

Google Scholar

[26] J.L. Arias, M. López-Viota, V. Gallardo, et al: Drug Development and Industrial Pharmacy Vol. 36 (2010), p.744.

Google Scholar

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