A Novel Three-Dimensional Direct Controlled Cell Assembling System

Abstract:

Solid freeform fabrication (SFF) technology has been widely used to fabricate three-dimensional (3D) cell constructs. As multi-cell construct is a heterogeneous object (He-Object), it is a trend of biomanufacturing to use SFF technology to fabricate multi-cell constructs. In this paper, a novel multi-nozzle deposition system, called as 3D direct controlled cell assembling (CA) system, was developed to fabricate 3D multi-cell constructs. The developed system design was demand-oriented and applied functional modular design method. As the key part of this system, the multi-nozzle system was designed and described in details. Experimental study was conducted and results showed that the system could meet the requirements of the process and be used to fabricate complex 3D cell constructs. By comparison, the developed system could precisely deposite biomaterials with high viscocity and form constructs with big size in continuous deposition mode.

• Periodical: Advanced Materials Research (Volumes 652-654)
• Pages: 2079-2085
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.652-654.2079
• Online since: January 2013
• Authors: Yu Li, Lei Zhang, Chang Yong Liu, Yu Zhao, Wei Sun
• Keywords: Cell Assembling, Multi-Cell Constructs, Multi-Nozzle System, Solid Freeform Fabrication

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