Optimized Formulation of APN Toothpaste with Biochemical Materials Using Response Surface Methodology

Ting Kong; Chao Yan Zhang; Bin Bao; Long Sha; Zhen Wang; Wen Hui Wu

doi:10.4028/www.scientific.net/AMR.676.108

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 676Optimized Formulation of APN Toothpaste with...

Optimized Formulation of APN Toothpaste with Biochemical Materials Using Response Surface Methodology

Abstract:

Response surface methodology(RSM) was used to optimize the formulation of one toothpaste with aglycone extracted from Panax notoginseng(APN). Biochemical materials are important components in toothpastes. The addition amount of APN, thickener, different ratios of humectant and friction agent were selected as three factors for the design. Our results showed that the experimental data could be adequately fitted into a second-order polynomial model. Addition amount of thickener and humectant : friction agent had a significant effect on the composite score. The optimum formulation for preparing APN toothpaste was predicted to be: APN, 0.12%; thickener, 1.58%; humectant : friction agent, 1.01.

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Periodical:

Advanced Materials Research (Volume 676)

Pages:

108-113

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.676.108

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Online since:

March 2013

Authors:

Ting Kong, Chao Yan Zhang, Bin Bao, Long Sha, Zhen Wang, Wen Hui Wu

Keywords:

Biochemical Materials, Formulation Design, Response Surface Methodology (RSM), Toothpaste

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