For the excellent characters such as lightweight, high ratio-strength, high rigidity and reuse, magnesium alloy is used widely in vehicle lightweight redesign. Selecting AM60B as material, the process of magnesium alloy material substitution redesign for wheels of electric bicycle is advanced. The structure of aluminum alloy wheel is chosen as prototype structure for magnesium alloy wheel according to the similarity between the properties of aluminum alloy and magnesium alloy. The structure redesign optimized parametric model is put forward by the stimulation analysis of static load test and dynamic bending fatigue test. The inspection of samples shows that the structure redesign is feasible, and the target of wheels lightweight redesign is achieved.