A Novel 5-Fluorouracil-Loaded Polyelectrolyte Nanoparticle Formulation

Abstract:

To successfully prepare drug delivery system, nanoparticles (NPs) with simple and effective method avoiding use of potentially toxic solvent and components, 5-fluorouracil (5-Fu) was chosen as a model low molecular weight chemotherapeutic drug and 5-Fu- loaded NPs were prepared with the lecithin emulsified method following the alginate solidification and chitosan aggregation. Prescription was optimized by orthogonal experiment. The resultant 5-Fu NPs had a spherical structure with a diameter about 200 nm. The encapsulation efficiency of 5-Fu NPs is 55.36 ± 1.10%. The loading capacity is 4.22 ± 0.14%.

• Periodical: Advanced Materials Research (Volumes 690-693)
• Pages: 518-522
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.690-693.518
• Online since: May 2013
• Authors: Yu Ling Fan*, Bing Yu Fan, Qiang Li, Shuang Leng, Li Hua Ma
• Keywords: 5-Fluorouracil, Polyelectrolyte Nanoparticles

References

[1] Wang X., Wang YQ., Chen ZG., Shin DM., Advances of Cancer Therapy by Nanotechnology. Cancer Res Treat. 41(1) (2009), 1-11.

[2] Medina C., Santos-Martinez MJ., Radomski A., Corrigan OI., Radomski MW., Nanoparticles: pharmacological and toxicological significance. British Journal of Pharmacology. 150(5) (2007), 552–558.

DOI: 10.1038/sj.bjp.0707130

[3] Zhang Y., Zhuo RX., Synthesis，characterization，and in vitro 5-fu release behavior of oly(2,2-dimethyltrimethylenecarbonate)-poly(ethyleneglycol)-poly(2,2-dimethyltrimethylenecarbonate) nanoparticles. Journal of Biomedical Materials Research. 76(4) (2006), 674-680.

DOI: 10.1002/jbm.a.30395

[4] Nair KL., Jagadeeshan S., Nair SA., Kumar GS., Biological evaluation of 5-fuorouracil nanoparticles for cancer chemotherapy and its dependence on the carrier, PLGA. International Journal of Nanomedicine. 6(2011)1685-1697.

DOI: 10.2147/ijn.s20165

[5] You J., Liu YC., Peng CA., Effcient gene transfection using chitosan–alginate core-shell nanoparticles. International Journal of nanomedicine. 1(2) (2006)-180.

DOI: 10.2147/nano.2006.1.2.173

[6] Hartig SM., Greene RR., Dasgupta J., Carlesso G., Dikov MM., Prokop A., Davidson JM., Multifunctional Nanoparticulate Polyelectrolyte Complexes. Pharmaceutical Research. 24(12) (2007) 98-2206.

DOI: 10.1007/s11095-008-9623-2

[7] Nagpal K., Singh SK., Mishra DN., Chitosan Nanoparticles: A Promising System in Novel Drug Delivery. Chem. Pharm. Bull. 58(11) (2010) 3-1430.

DOI: 10.1248/cpb.58.1423

[8] Hamman JH., Chitosan Based Polyelectrolyte Complexes as Potential Carrier Materials in Drug Delivery Systems. Mar. Drugs. 8(2010) 305-1322.

DOI: 10.3390/md8041305

[9] Ahmad Z., Khuller GK., Alginate-based sustained release drug delivery systems for tuberculosis. Expert Opin Drug Deliv. 5(12) (2008) 23-34.

DOI: 10.1517/17425240802600662

[10] Reis CP., Neufeld RJ., Vilela S., Ribeiro AJ., Veiga F., Review and current status of emulsion/dispersion technology using an internal gelation process for the design of alginate particles. J Microencapsul. 23(3) (2006) 5-57.

DOI: 10.1080/02652040500286086

[11] Grem JL., 5-Fluorouracil: forty-plus and still ticking. A review of its preclinical and clinical development. Invest New Drugs. 18(4) (2000) -313.

DOI: 10.1023/a:1006416410198

[12] Llorca FC., Esquerdo GG., Cervera GJ., Gervera GJM., Briceno GHC., Calduch BJV., Delpino CJ., 5-Fluorouracil-induced small bowel toxicity in a patient with colorectal cancer. Clin Transl Oncol. 7(8) (2005) 6-357.